New horizons in treating metastatic disease

Clinical Breast Cancer
M Cristofanilli, G N Hortobagyi

Abstract

The management of metastatic breast cancer is changing as a consequence of extraordinary discoveries in cancer research and the development of more advanced diagnostic technologies. Although traditional chemotherapeutics such as anthracyclines and taxanes still represent the mainstay of treatment for this disease, new drugs are demonstrating significant clinical activity and sometimes a better toxicity profile. Furthermore, the successful introduction into clinical practice of biological agents, in particular the monoclonal antibody trastuzumab, offers a key to the future of managing metastatic breast cancer. A therapeutic approach based on modifications of a specific molecular target (e.g., gene therapy, vaccines, and antiangiogenesis) alone or combined with the traditional chemotherapeutic drugs is expected to be used more commonly and will, we hope, bring significant improvement in the clinical response and quality of care of our patients.

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P CarterH M Shepard
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P ShawJ Costa
Dec 18, 1991·Journal of the National Cancer Institute·F A HolmesG N Hortobagyi
Feb 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T HabeshawE M Rankin
Apr 1, 1989·Clinical Pharmacokinetics·R B Diasio, B E Harris
Jun 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Italian Multicentre Breast Study with EpirubicinC Intini
Apr 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J LokichJ G Fryer
Mar 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J Cersosimo, W K Hong
Apr 5, 1985·Science·W J Hrushesky
May 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A D SeidmanP Forsythe
Oct 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A D SeidmanJ Crown
Jun 1, 1995·Anti-cancer Drugs·A T van OosteromD ] Schriivers D [corrected to Schrijvers
Jan 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D AbigergesD Gandia
Dec 1, 1993·British Journal of Cancer·J E LiebmannJ B Mitchell
Aug 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W H WilsonJ O'Shaughnessy
Nov 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R PazdurB Bready
May 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H BurrisG Rodriguez
Jul 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C FocanF Ries
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J KajantiA G Maiche
Dec 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V ValeroG N Hortobagyi
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J BaselgaL Norton
Feb 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M E TrudeauA M Muldal
Jun 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A D SeidmanL Norton
Feb 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P FumoleauH Roche
Sep 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J GehlP Dombernowsky
Dec 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S D BakerE K Rowinsky
Dec 13, 1996·Annals of the New York Academy of Sciences·J G LiehrB C Giovanella
Jul 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A EzzatA el-Warith
Mar 20, 1998·International Journal of Cancer. Journal International Du Cancer·M V Blagosklonny, W S El-Deiry
May 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D R BudmanT Griffin
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G F FlemingE E Vokes
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J D HainsworthF A Greco

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Citations

Oct 6, 2006·Expert Review of Anticancer Therapy·Julia MandelblatDaniel R Budman
Apr 29, 2008·Journal of Vascular and Interventional Radiology : JVIR·Tobias F JakobsThomas K Helmberger
Feb 20, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·S A Kaestner, G J Sewell
Jun 26, 2008·Cardiovascular and Interventional Radiology·Tobias F JakobsMaximilian F Reiser
Sep 14, 2019·Cancers·Reto BalePeter Schullian
Apr 4, 2021·Journal of Personalized Medicine·Armando OrlandiGiampaolo Tortora

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