New Hormonal Agents in Patients With Nonmetastatic Castration-Resistant Prostate Cancer: Meta-Analysis of Efficacy and Safety Outcomes

Clinical Genitourinary Cancer
Vincenzo Di NunnoFrancesco Massari

Abstract

In the past few years several hormonal agents have been tested in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC) leading to an impressive improvement in terms of metastases-free survival (MFS). We performed a meta-analysis aimed to: (1) estimate the pooled effect of new hormonal compounds in terms of MFS, overall survival (OS) in overall and specific subpopulations; and (2) estimate the effect of high-grade toxicities of these drugs. We identified 881 studies published between January 1, 2010 and February 16, 2018 on PubMed/Medline, Cochrane Library, and Scopus. Three randomized placebo controlled clinical trials were selected (PROSPER, SPARTAN, and ARAMIS). Because of the absence of individual data, all of the analyses performed were made on aggregated data provided in selected studies. We used the inverse variance technique for the meta-analysis of the hazard ratios collected for MFS and OS analysis. Fixed and randomized models were used. Relative risk and 95% confidence intervals and risk difference were estimated considering the number of Grade 3 adverse events in treatment and control arms. Administration of new hormonal compounds in nmCRPC patients led to a significant benefit in MFS in the over...Continue Reading

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Citations

Oct 17, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G RovielloE Mini
Aug 9, 2020·Cancer Management and Research·E David CrawfordDivneet Mandair
Jan 17, 2021·International Journal of Molecular Sciences·Viviana M BimonteAntonio Aversa
Mar 10, 2021·Expert Review of Clinical Pharmacology·Valeria Emma PalmieriRoberta Giorgione
Apr 19, 2021·Current Treatment Options in Oncology·Azariyas A ChallaAvirup Guha
Jul 4, 2021·Current Cardiology Reports·Julia BolandJianqing Lin

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