PMID: 6411995Jul 1, 1983Paper

New hormonal treatment in cancer of the prostate: combined administration of an LHRH agonist and an antiandrogen

Journal of Steroid Biochemistry
F LabrieA T Fazekas

Abstract

At doses which have no or minimal inhibitory effect when administered alone, the LHRH agonist [D-Ser(TBU)6,des-Gly-NH10(2)] LHRH ethylamide (HOE-766) and the antiandrogen RU-23908 administered simultaneously cause a marked inhibition of ventral prostate and seminal vesicle weight after 5 months of treatment. The effect of the LHRH agonist is due to a blockage of the testicular steroidogenic pathway. The same LHRH agonist administered to adult men with cancer of the prostate causes a marked inhibition of serum testosterone and dihydrotestosterone to castration levels within 1-2 weeks. Administration of the pure antiandrogen to men with cancer of the prostate already receiving the LHRH agonist does not interfere with the LHRH agonist-induced blockage of androgen biosynthesis: Moreover, objective signs of remission of the disease were rapidly observed in 8 out of 10 patients. The ease of application of this new form of hormonal therapy which neutralizes androgens from all sources should facilitate its early administration and thus minimize the development of metastases and androgen-resistant cell clones.

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Citations

Nov 1, 1986·Journal of Steroid Biochemistry·F Di Silverio, F Sciarra
Jan 1, 1987·Journal of Steroid Biochemistry·S A Shain, R I Huot
Oct 1, 1988·Journal of Steroid Biochemistry·S A Shain, R I Huot
Jan 24, 1991·The New England Journal of Medicine·R F Gittes
Mar 24, 2011·Future Medicinal Chemistry·Tadas S Vasaitis, Vincent C O Njar
Oct 26, 2013·Expert Opinion on Pharmacotherapy·Rahul R DeshmukhQing Ping Dou
Nov 21, 2007·Bioorganic & Medicinal Chemistry Letters·Mariano A E Pinto-Bazurco MendietaRolf W Hartmann
Apr 5, 2008·International Journal of Cancer. Journal International Du Cancer·Yi CaiChawnshang Chang
Jan 1, 1989·Journal of Surgical Oncology. Supplement·A D SeftelM I Resnick
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·G W Chodak, G J C M Kolvenbag
Jun 1, 1995·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D W Newling

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