New idea for treatment strategies for Barcelona Clinic Liver Cancer stages based on a network meta-analysis

Medicine
Kun LiTao Guo

Abstract

Currently, the Barcelona Clinic Liver Cancer staging (BCLC) system still remains controversies in the management of hepatocellular carcinoma. We are trying to determine the best therapeutic strategy for each BCLC stage through a network meta-analysis and provide a new treatment idea. We conducted a systematic literature search of the PubMed, EMBASE, and Cochrane Library databases and extracted data from randomized controlled trials (RCTs) that compared various strategies. Network meta-analyses were conducted in ADDIS by evaluating different overall survival of each stage. Cumulative probability was used to rank the included strategies. A node-splitting model assessed whether direct and indirect evidence on a specific node was in agreement. Of the 24 included RCTs, 3667 patients were included. Based on the probability P values, the results showed that TACE plus surgical resection (SR) was the first choice for BCLC Stage A (P = .38 and P = .52 for 3- and 5-year OS, respectively). The application of SR was the best strategy for BCLC Stage B (P = .51 and P = .95 for 1- and 3-year OS, respectively). For Stage C, whole net connections could not be established in this research, but combined therapy seemed to produce better results bas...Continue Reading

References

Oct 13, 1999·Seminars in Liver Disease·J M LlovetJ Bruix
Jan 31, 2002·World Journal of Gastroenterology : WJG·J FanS L Ye
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Josep M LlovetUNKNOWN Barcelona-Clínic Liver Cancer Group
Mar 26, 2004·Journal of Cancer Research and Clinical Oncology·Bo-Heng ZhangZhao-You Tang
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Oct 11, 2007·Statistical Methods in Medical Research·Georgia SalantiJohn P A Ioannidis
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·J M HendersonT Gramlich
May 21, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Jeroen P JansenWiro Stam
Jun 24, 2008·Scandinavian Journal of Gastroenterology·Franco BrunelloMario Rizzetto
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Oct 5, 2010·Journal of Surgical Oncology·Tito LivraghiGuido Torzilli
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Oct 11, 2013·Future Oncology·Gaetano BertinoMichele Malaguarnera
May 2, 2014·Gastroenterology·Morris Sherman

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Methods Mentioned

BETA
surgical resection

Software Mentioned

RevMan5
Aggregate Data Drug Information System ( ADDIS

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