PMID: 1201267Nov 1, 1975Paper

New inhibitors of methane production by rumen micro-organisms. Development and testing of inhibitors in vitro

The British Journal of Nutrition
J W Czerkawski, G Breckenridge

Abstract

1. A procedure is described for assaying in vitro the activity of various inhibitors of methane production by rumen micro-organisms. 2. Methods of preparation of various inhibitors are described together with attempts to characterize these compounds by determining their physical properties (physical state, density, chromatographic behaviour), their hydrolysis by rumen contents and their relative potency as inhibitors. 3. The results of preliminary studies with trichloroethanol and its ester with pivalic acid are given. 4. The inhibitory activities of several groups of related compounds are reported. These include the polyhalogenated alcohols and their esters with pivalic acid, the esters of trihalogenated alcohols and monobasic fatty acids from C2 and C16 and the trihalogenated alcohol esters of dibasic acids. The results of experiments with esters of alcohols and polyhalogenated carboxylic and sulphonic acids are also given. 5. It is concluded that the mechanism of action of the inhibitors might be similar to that of known polyhalogenated methane analogues (e.g. chloroform). The relative activity of various compounds might be partly governed by the ease of their absorption into the microbial cells and by the extent to which th...Continue Reading

References

Jan 1, 1972·Antonie van Leeuwenhoek·R A PrinsD I Demeyer
Sep 1, 1972·The Proceedings of the Nutrition Society·J W Czerkawski
Mar 1, 1973·The British Journal of Nutrition·J W Czerkawski, G Breckenridge
Apr 1, 1974·Journal of Animal Science·M S SawyerC J Sniffen
Dec 3, 1971·Nature·B C McBride, R S Wolfe
Mar 1, 1972·Journal of Animal Science·J E TreiR C Parish
Nov 1, 1971·The British Journal of Nutrition·J L Clapperton, J W Czerkawski
Apr 1, 1971·Journal of Dairy Science·J E TreiY K Singh
May 1, 1964·Journal of Bacteriology·E A WolinM J Wolin
Sep 1, 1966·Journal of the Science of Food and Agriculture·K L Blaxter, J Czerkawski
Feb 1, 1966·Biochemistry·H P Hogenkamp
Jul 1, 1967·The Journal of Pathology and Bacteriology·R O Weller
Jun 6, 1967·Biochimica Et Biophysica Acta·D I Demeyer, H K Henderickx
Jul 1, 1965·Journal of Dairy Science·R A PRINS
Jan 1, 1949·Antonie van Leeuwenhoek·M A NOORDAM-GOEDEWAGENF M MULLER

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Citations

Nov 1, 1987·The British Journal of Nutrition·M Wakita, S Hoshino
Feb 1, 1981·Archiv für Tierernährung·C J van Nevel, D I Demeyer
Sep 1, 1981·Journal of Veterinary Pharmacology and Therapeutics·M AmgartenA Wüthrich

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