New insight into GABAergic neurons in the hypothalamic feeding regulation

The Journal of Physiological Sciences : JPS
Shigetomo Suyama, Toshihiko Yada

Abstract

Several lines of study have suggested that GABA in the hypothalamic feeding center plays a role in promoting food intake. Recent studies revealed that not only NPY/AgRP neurons in the hypothalamic arcuate nucleus (ARC) that co-express GABA but also other GABAergic neurons act as an orexigenic. Here, we review the progress of studies on hypothalamic GABAergic neurons distributed in ARC, dorsomedial hypothalamus (DMH), and lateral hypothalamus (LH). Three advanced technologies have been applied and greatly contributed to the recent progress. Optogenetic (and chemogenetic) approaches map input and output pathways of particular subpopulations of GABAergic neurons. In vivo Ca2+ imaging using GRIN lens and GCaMP can correlate the activity of GABAergic neuron subpopulations with feeding behavior. Single-cell RNA-seq approach clarifies precise transcriptional profiles of GABAergic neuron subpopulations. These approaches have shown diversity of GABAergic neurons and the subpopulation-dependent role in feeding regulation.

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Citations

Mar 17, 2020·Journal of Cellular and Molecular Medicine·Tong Tong GeBing Jin Li
Oct 17, 2019·Neuropsychopharmacology Reports·Naomi YonemochiHiroko Ikeda
Sep 17, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrew R RauShane T Hentges
Jul 3, 2021·International Journal of Environmental Research and Public Health·Marta G Novelle
Jul 3, 2021·International Journal of Molecular Sciences·Darren MehayAmy C Arnold
Aug 4, 2021·Open Biology·Joshua Wang, Kate Beecher
Nov 4, 2021·The Journal of Clinical Investigation·Danielle E WhittakerMehul T Dattani

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Methods Mentioned

BETA
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