New insight on the response of bacteria to fluoride.

Caries Research
Ronald R Breaker

Abstract

Fluoride has been used for decades to prevent caries and it is well established that this anion can inhibit the growth of bacteria. However, the precise effects that fluoride has on bacteria and the mechanisms that bacteria use to overcome fluoride toxicity have largely remained unexplored. Recently, my laboratory reported the discovery of biological systems that bacteria use to sense fluoride and reduce fluoride toxicity. These sensors and their associated genes are very widespread in biology, which has implications for a number of issues that are central to the use of fluoride for dental care. Below I provide a summary of our findings, comment on some of the key prospects for expanding our understanding of fluoride's effects on biology, and propose some future uses of this knowledge.

References

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Citations

Aug 27, 2014·The Journal of General Physiology·Chunhui JiChristopher Miller
Sep 23, 2014·Archives of Oral Biology·Cristiane de Almeida Baldini CardosoMarília Afonso Rabelo Buzalaf
Feb 4, 2014·Organic Letters·Michal S HallsideAndrew J Phillips
Apr 5, 2013·Journal of Biomedical Materials Research. Part a·Furqan A ShahKarin A Hing
Feb 24, 2015·Environmental Science & Technology·Hans K CarlsonJohn D Coates
May 20, 2015·Journal of International Society of Preventive & Community Dentistry·Mohan JothikaBattu Someshwar
May 18, 2016·FEMS Microbiology Letters·Takatoshi Murata, Nobuhiro Hanada
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Furqan A Shah
Apr 30, 2017·The Journal of Biological Chemistry·Joseph E WedekindJermaine L Jenkins
Oct 8, 2014·Nature Communications·Randy B StockbridgeShohei Koide
Apr 11, 2020·Chembiochem : a European Journal of Chemical Biology·Manuel Nieto-Domínguez, Pablo I Nikel
Jul 28, 2017·Journal of Oral Microbiology·Ying LiaoDong Mei Deng
Mar 9, 2020·Environmental Science and Pollution Research International·Priya KatiyarKeshav Kant Sahu
Oct 6, 2020·Journal of Environmental Quality·Thangavelautham GeretharanChristopher W N Anderson
Jan 30, 2021·Frontiers in Chemistry·Zhixing ZhaoYun-Bao Jiang
Jul 21, 2020·ACS Chemical Biology·Ronald R Breaker
Oct 13, 2021·ACS Nano·Xuechen ZhouMenachem Elimelech

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