New insights: A role for O-GlcNAcylation in diabetic complications

Critical Reviews in Biochemistry and Molecular Biology
Sherket B Peterson, Gerald W Hart

Abstract

Diabetes is a debilitating metabolic disease that is riddled with complications that can cause blindness, renal failure, nerve damage, and cardiovascular disease. Poor glycemic control is thought to be a key initiator in the progression of diabetic complications. Hyperglycemia has been shown to increase flux through the hexosamine biosynthetic pathway (HBP) to initiate many of the toxic effects of glucose. The major endpoint of the HBP is the formation of uridine diphosphate β-D-N-acetylglucosamine (UDP-GlcNAc), the donor for protein O-GlcNAcylation, and complex extracellular glycosylation. O-GlcNAcylation is a dynamic nutrient sensitive post-translational modification that is characterized by the addition of single β-D-N-acetylglucosamine to the serine and/or threonine residues of almost every functional class of protein. O-GlcNAc is extremely abundant and cycles on and off proteins by the concerted action of a transferase and a hydrolase. O-GlcNAc serves as a nutrient/stress sensor regulating several processes, such as signaling, transcription, cytoskeletal dynamics, and cell division. Altered O-GlcNAc signaling is directly involved in the pathogenesis of diabetes and new insights are revealing the importance of O-GlcNAc in d...Continue Reading

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
May 29, 1998·Circulation·P W WilsonW B Kannel
Aug 5, 1999·Kidney International·G Wolf, F N Ziyadeh
Nov 5, 1999·The Journal of Biological Chemistry·L K Kreppel, G W Hart
Dec 2, 1999·Biochimica Et Biophysica Acta·F I Comer, G W Hart
Feb 7, 2001·The Journal of Biological Chemistry·W A Lubas, J A Hanover
May 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·R ShafiJ D Marth
Aug 23, 2000·The Journal of Clinical Investigation·H N Ginsberg
Sep 21, 2000·Kidney International. Supplement·G Wolf
Feb 24, 2001·Current Opinion in Nephrology and Hypertension·A S Shaw, J H Miner
Jun 21, 2001·Molecular and Cellular Biology·D B DonovielD R Powell
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Keith VossellerGerald W Hart
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Donald A McClainJohn A Hanover
Oct 25, 2002·American Journal of Physiology. Endocrinology and Metabolism·Jennie L E WalgrenMaria G Buse
Nov 19, 2002·The Journal of Biological Chemistry·Sai Prasad N IyerGerald W Hart
Dec 31, 2002·Archives of Biochemistry and Biophysics·John A HanoverDona C Love
Jan 23, 2003·Journal of Cell Science·Dona C LoveJarema Kochran
Feb 25, 2003·Progress in Retinal and Eye Research·A N WitmerR O Schlingemann
Aug 27, 2003·Investigative Ophthalmology & Visual Science·Yoshihiro AkimotoHiroshi Hirano
Aug 28, 2003·The Journal of Biological Chemistry·Raymond J ClarkWolfgang H Dillmann
Sep 1, 1961·Archives of Ophthalmology·D G COGANT KUWABARA
Dec 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Maria G Buse

❮ Previous
Next ❯

Citations

Jun 5, 2016·Molecular Aspects of Medicine·Partha S BanerjeeGerald W Hart
Jul 28, 2016·Journal of Pharmaceutical and Biomedical Analysis·Sachio YamamotoShigeo Suzuki
Jan 6, 2017·ACS Chemical Biology·Matthew WorthJiaoyang Jiang
Feb 15, 2018·International Journal of Molecular Sciences·Bastian SchirmerKatharina F Kubatzky
Feb 17, 2017·Physiology·Laura BierhanslPeter Carmeliet
Dec 1, 2017·Malaria Journal·Mattis KupferschmidTony Lefebvre
Jun 7, 2018·The Journal of Biological Chemistry·Diogo de Barros PeruchettiCelso Caruso-Neves
Jan 12, 2019·Pharmaceutical Patent Analyst·Hermann Am Mucke
Jan 11, 2019·The Journal of Biological Chemistry·Gerald W Hart
May 16, 2019·Journal of Zhejiang University. Science. B·Hao Nie, Wen Yi
Jul 4, 2019·American Journal of Physiology. Renal Physiology·Mengqiu WuZhanjun Jia
Feb 6, 2020·Intellectual and Developmental Disabilities·Minkowan GooRobert Serwetz
Jul 26, 2018·International Journal of Molecular Sciences·Su Jin LeeOh-Shin Kwon
Nov 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·James BiwiTony Lefebvre
Feb 23, 2019·Molecular Reproduction and Development·Luhan T ZhouFrancesca E Duncan
Jul 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yunfan YangXiaoyong Yang
Feb 6, 2018·The Journal of Clinical Investigation·Sun-Hye JeongDae-Sik Lim
Nov 22, 2018·Frontiers in Endocrinology·Matthias LambertCaroline Cieniewski-Bernard
Oct 1, 2019·American Journal of Physiology. Renal Physiology·Yoshihiro AkimotoHayato Kawakami
Nov 8, 2020·Cell Stress & Chaperones·Yang LiuShi-Ze Li
Dec 2, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ilaria ZulianiFabio Di Domenico
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Roberta CostaSilvia Dossena
Jul 22, 2019·Current Opinion in Structural Biology·Weston B Struwe, Carol V Robinson
Jan 13, 2021·The Journal of Biological Chemistry·Muhammad Abid SheikhSuraiya Anjum Ansari
Nov 7, 2020·The Journal of Biological Chemistry·Muhammad Abid SheikhSuraiya Anjum Ansari
Dec 18, 2020·Frontiers in Chemistry·Raid AlhayazaM Ruhul Abid
Feb 22, 2021·The Journal of Biological Chemistry·Villő MuhaDaan M F van Aalten
Jul 31, 2020·Physiological Reviews·John C ChathamAdam R Wende
Aug 2, 2020·Molecular Aspects of Medicine·Yi Zhu, Gerald W Hart
Jun 7, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sushmita Bora, Prashant Shankarrao Adole
Jun 9, 2021·Chembiochem : a European Journal of Chemical Biology·Eun Ju Kim
Aug 3, 2021·Chemical Society Reviews·Abhijit SahaAlberto Fernández-Tejada
Aug 3, 2019·Journal of the American Chemical Society·Cassandra M JoinerSuzanne Walker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.