New insights about the regulation of Nidovirus subgenomic mRNA synthesis

Virology
Han DiMargo A Brinton

Abstract

The members of the Order Nidovirales share a similar genome organization with two overlapping nonstructural polyproteins encoded in the 5' two-thirds and the structural proteins encoded in the 3' third. They also express their 3' region proteins from a nested set of 3' co-terminal subgenomic messenger RNAs (sg mRNAs). Some but not all of the Nidovirus sg mRNAs also have a common 5' leader sequence that is acquired by a discontinuous RNA synthesis mechanism regulated by multiple 3' body transcription regulating sequences (TRSs) and the 5' leader TRS. Initial studies detected a single major body TRS for each 3' sg mRNA with a few alternative functional TRSs reported. The recent application of advanced techniques, such as next generation sequencing and ribosomal profiling, in studies of arteriviruses and coronaviruses has revealed an expanded sg mRNA transcriptome and coding capacity.

Citations

Jun 29, 2018·Journal of Virology·Hazel StewartAndrew E Firth
Jul 15, 2020·The Journal of Biological Chemistry·Ella HartenianBritt A Glaunsinger
Oct 30, 2020·Nature Reviews. Microbiology·Philip V'kovskiVolker Thiel
Mar 12, 2021·Virus Research·Santiago Emanuel ColinaGermán Ernesto Metz
Aug 26, 2021·Journal of Infection and Public Health·Tahmeena FarooqiSirajudheen Anwar

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

MassSpec

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