New insights from the widening homogeneity perspective to target intratumor heterogeneity

Cancer Communications
Mengying TongQuentin Liu

Abstract

Precision medicine has shed new light on the treatment of heterogeneous cancer patients. However, intratumor heterogeneity strongly constrains the clinical benefit of precision medicine. Thus, rethinking therapeutic strategies from a different facet within the precision medicine framework will not only diversify clinical interventions, but also provide an avenue for precision medicine. Here, we explore the current approaches for targeting intratumor heterogeneity and their limitations. Furthermore, we propose a theoretical strategy with a "homogenization" feature based on iatrogenic evolutionary selection to target intratumor heterogeneity.

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Citations

Jan 16, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jordan AyersMarc Salute
May 24, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Amir Iravani, Rodney J Hicks

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

TRACERx

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