New Insights in Anti-Angiogenesis in Multiple Myeloma

International Journal of Molecular Sciences
Domenico Ribatti, Angelo Vacca

Abstract

Angiogenesis is a constant hallmark of multiple myeloma (MM) progression and involves direct production of angiogenic cytokines by plasma cells and their induction within the bone marrow microenvironment. This article summarizes the more recent literature data concerning the employment of anti-angiogenic therapeutic agents actually used in preclinical models and clinical settings for the treatment of multiple myeloma.

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Citations

Jun 4, 2019·International Journal of Molecular Sciences·Zsombor Melegh, Sebastian Oltean
Jan 16, 2020·International Journal of Molecular Sciences·Anubhab MukherjeeSudip Mukherjee
Feb 23, 2020·Journal of Clinical Medicine·Giuseppe Di LerniaVito Racanelli
Jan 26, 2021·Frontiers in Oncology·Anna RussignanCristina Tecchio
Oct 31, 2020·Cancers·Daniela IannazzoAlessandra Bitto
Mar 21, 2021·European Journal of Pharmacology·Digna Parmar, Madhavi Apte
Apr 4, 2021·Cancers·Raquel LopesCristina João
Jun 3, 2021·Cancers·Roberto RoncaArianna Giacomini
May 29, 2021·Molecular Aspects of Medicine·Luana TomaipitincaGiovanni Bernardini

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Methods Mentioned

BETA
FACS
xenograft

Clinical Trials Mentioned

NCT03136653

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