New Insights in the Endocrine Disrupting Effects of Three Primary Metabolites of Organophosphate Flame Retardants

Environmental Science & Technology
Quan ZhangCui Wang

Abstract

Despite the ubiquity of organophosphate flame retardants (OPFRs) metabolites in the biota, the endocrine disrupting potency has not been well examined. Herein, we chose three primary metabolites of OPFRs (BCIPP, BDCIPP, and DPHP) to investigate their potential endocrine disrupting effects by in vitro, in vivo, and in silico assays. Three metabolites were agonistic to rat estrogenic receptor alpha (ERα) and antagonists to human mineralocorticoid receptor (MR). BCIPP exerted endocrine disrupting effect contrasting to the negative response of its parental compound. It also poses the strongest binding capacity to ERα among the tested compounds. Both BCIPP and BDCIPP upregulated the genes encoded for estrogenic synthesis enzymes in H295R cells, including 17βHSD and CYP19. All three compounds stimulated the transcription of CYP11B1, whereas BCIPP and DPHP also triggered CYP11B2, encoding for corticoid production. BDCIPP inhibits genes for progesterone synthesis including CYP11A1, STAR, and 3-βHSD. The induction of mortality and low hatchability of zebrafish embryo were ranked as BCIPP ≥ BDCIPP > DPHP. All compounds lead to malformation of zebrafish larvae. Both of the hypothalamic-pituitary-adrenocortical and hypothalamic-pituitary-g...Continue Reading

References

Sep 1, 1984·Bulletin of Environmental Contamination and Toxicology·K SasakiM Uchiyama
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jan 6, 2006·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S A KulkarniS Blechinger
Feb 7, 2007·Journal of Neuroendocrinology·T OchedalskiG Aguilera
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Karen A KiddRobert W Flick
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Daniel A GorelickMarnie E Halpern
Jan 6, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Birgit Karin SchindlerJürgen Angerer
Apr 13, 2010·Journal of Environmental Monitoring : JEM·Anneli Marklund SundkvistPeter Haglund
Apr 20, 2010·Journal of Environmental Sciences (China)·Meiqing JinMeirong Zhao
Sep 21, 2010·Environmental Toxicology and Chemistry·Ying ZhangWeiping Liu
Feb 22, 2011·The Science of the Total Environment·Thorsten ReemtsmaStefanie Roegler
May 20, 2011·Environmental Science & Technology·Heather M StapletonArlene Blum
Jul 26, 2011·Journal of Hazardous Materials·Natsuko KajiwaraHidetaka Takigami
Aug 31, 2011·Behavioural Brain Research·Michail PavlidisPertti Panula
Dec 10, 2013·Environment International·Kate HoffmanHeather M Stapleton
May 23, 2014·Environmental Science & Technology·Quan ZhangMeirong Zhao
Apr 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Aekkapot Chamkasem, Waraphan Toniti
Dec 23, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Laverne Camille Melón, Jamie Maguire
Apr 22, 2017·Environmental Science & Technology·Quan ZhangMeirong Zhao

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Citations

Aug 28, 2020·Neurotoxicology and Teratology·Mathan RameshSathisaran Umamaheswari

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