New Insights into ADAMTS Metalloproteases in the Central Nervous System.

Biomolecules
Yamina MohamediÁlvaro J Obaya

Abstract

Components of the extracellular matrix (ECM) are key players in regulating cellular functions throughout the whole organism. In fact, ECM components not only participate in tissue organization but also contribute to processes such as cellular maintenance, proliferation, and migration, as well as to support for various signaling pathways. In the central nervous system (CNS), proteoglycans of the lectican family, such as versican, aggrecan, brevican, and neurocan, are important constituents of the ECM. In recent years, members of this family have been found to be involved in the maintenance of CNS homeostasis and to participate directly in processes such as the organization of perineural nets, the regulation of brain plasticity, CNS development, brain injury repair, axonal guidance, and even the altering of synaptic responses. ADAMTSs are a family of "A disintegrin and metalloproteinase with thrombospondin motifs" proteins that have been found to be involved in a multitude of processes through the degradation of lecticans and other proteoglycans. Recently, alterations in ADAMTS expression and activity have been found to be involved in neuronal disorders such as stroke, neurodegeneration, schizophrenia, and even Alzheimer's diseas...Continue Reading

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Citations

May 15, 2020·Molecular Psychiatry·Sarah E WilliamsRichard D Cummings
Feb 11, 2021·Journal of Biochemistry·Mitsuharu Hattori, Takao Kohno
Apr 4, 2021·International Journal of Molecular Sciences·Tania FontanilSantiago Cal
Aug 30, 2021·Molecular Neurodegeneration·M Mahafuzur Rahman, Christofer Lendel

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Methods Mentioned

BETA
glycosylation
transgenic

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