New insights into cardiovascular and lipid metabolomics

Journal of Cellular Biochemistry
Alfonso GiovaneClaudio Napoli

Abstract

Metabolomics is the study of metabolite profiles in biological samples, particularly urine, saliva, blood plasma and fat biopsies. The metabolome is now considered by some to be the most predictive phenotype: consequently, the comprehensive and quantitative study of metabolites is a desirable tool for diagnosing disease, identifying new therapeutic targets and enabling appropriate treatments. A wealth of information about metabolites has been accumulated with global profiling tools and several candidate technologies for metabolomic studies are now available. Many high-throughput metabolomics methodologies are currently under development and have yet to be applied in clinical practice on a routine basis. In the cardiovascular field, few recent metabolomic studies have been reported so far. This minireview provides an updated overview of alternative technical approaches for metabolomics studies and reviews initial applications of metabolomics that relate to both cardiovascular disease and lipid metabolism research.

References

Nov 4, 2000·The Biochemical Journal·X HanR W Gross
Sep 25, 2003·Annual Review of Plant Biology·Wolfram Weckwerth
Jan 5, 2005·Trends in Biotechnology·Claudia BirkemeyerJoachim Kopka
May 17, 2005·Expert Review of Proteomics·Xianlin Han, Richard W Gross
Dec 14, 2005·Circulation·Marc S SabatineRobert E Gerszten
May 9, 2006·Current Opinion in Chemical Biology·Marco BetzHarald Schwalbe
Jun 10, 2006·Analytical Biochemistry·Nelly AraníbarLuciano Mueller
Jun 21, 2006·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Lucinda Km Summers
Aug 12, 2006·Omics : a Journal of Integrative Biology·Oliver FiehnRima Kaddurah-Daouk
Sep 7, 2006·Analytical and Bioanalytical Chemistry·Zhengzheng Pan, Daniel Raftery
Sep 9, 2006·The American Journal of Clinical Nutrition·Marianne C WalshMichael J Gibney
Sep 12, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·David J DixRobert J Kavlock
Oct 13, 2006·Methods in Molecular Biology·Tomoyoshi Soga
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Carolyn J AlbertDavid A Ford
Dec 23, 2006·Current Opinion in Chemical Biology·Michelle L Reyzer, Richard M Caprioli
Dec 28, 2006·Physiological Genomics·R M SalekJ L Griffin
Jan 2, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Maria A ConstantinouEmmanuel Mikros
Jan 5, 2007·Nucleic Acids Research·David S WishartLori Querengesser
Feb 1, 2007·Analytical Chemistry·Mark P StyczynskiGregory N Stephanopoulos
Feb 3, 2007·Journal of Proteome Research·Elizabeth J WantGary Siuzdak
Feb 24, 2007·Analytical Biochemistry·Tobias KindRobert H Weiss
Mar 22, 2007·Journal of Proteome Research·J van der GreefR N McBurney
Mar 23, 2007·Journal of Chromatography. a·Maria Rowena N Monton, Tomoyoshi Soga
Mar 27, 2007·The British Journal of Nutrition·E Katherine KemsleyIan J Colquhoun
Mar 31, 2007·Drug Discovery Today·Wayne Materi, David S Wishart
Apr 17, 2007·Journal of the American College of Cardiology·David T MillerDavid J Kwiatkowski
May 1, 2007·Journal of Chromatography. a·Mikko Katajamaa, Matej Oresic
May 22, 2007·Analytica Chimica Acta·Suzanne SmitChris G de Koster
Jun 5, 2007·Rapid Communications in Mass Spectrometry : RCM·Seetharaman Vaidyanathan, Royston Goodacre
Jun 9, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Miyako KusanoKazuki Saito
Jul 11, 2007·Journal of Mass Spectrometry : JMS·Shelley N JacksonAmina S Woods
Jul 11, 2007·Journal of Mass Spectrometry : JMS·John A McLeanRichard M Caprioli

❮ Previous
Next ❯

Citations

Sep 14, 2012·Applied Biochemistry and Biotechnology·Aihua ZhangXijun Wang
Dec 3, 2014·Gene·Ana Emília Holanda RolimLuzimar Gonzaga Fernandez
Nov 15, 2011·Journal of Proteomics·Aihua ZhangXijun Wang
Jun 12, 2010·Burns : Journal of the International Society for Burn Injuries·Xin-Ru LiuWei-Dong Zhang
May 5, 2009·Progress in Cardiovascular Diseases·Claudio Napoli, Francesco Cacciatore
Jan 29, 2011·Journal of Biomedicine & Biotechnology·Maria G BarderasGloria Alvarez-Llamas
Nov 20, 2012·Clinical Science·Aliki A RasmienaPeter J Meikle
Jul 16, 2010·Inflammatory Bowel Diseases·Hui-Ming LinLynnette R Ferguson
Sep 1, 2011·Expert Review of Endocrinology & Metabolism·André Marette, Gary Sweeney
Oct 31, 2017·Research and Practice in Thrombosis and Haemostasis·Hiroshi DeguchiJohn H Griffin
Dec 17, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Qi ZhangDi Wu
Jul 6, 2017·Biosensors·Jessica Z Kubicek-SutherlandHarshini Mukundan
Dec 11, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Abdulnaser AlkhalilJeffrey W Shupp
Mar 12, 2009·Journal of Proteome Research·Hui-Ming LinDaryl D Rowan
Apr 3, 2014·Journal of Proteome Research·Christina E KostaraEleni T Bairaktari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.