New Insights into Clonal Mast Cell Disorders Including Mastocytosis

Immunology and Allergy Clinics of North America
Sofija VolertasCem Akin

Abstract

Mastocytosis is a heterogeneous group of neoplasms that involve the clonal expansion of mast cells into one or more organ systems, which typically involves the skin and hematopoietic systems. Systemic mastocytosis consists of a multifocal infiltration of mast cells into various noncutaneous tissue sites, especially the bone marrow. Diagnosis requires tissue confirmation, and algorithms have been developed to assist clinicians in this process. The current classification system focuses on delineating prognostic categories. Therapeutic approaches include symptomatic management, prevention of complications, and, in advanced disease, cytoreductive therapy.

Citations

Aug 2, 2020·Cytometry. Part B, Clinical Cytometry·Devasis PandaPrashant R Tembhare
Apr 28, 2019·Current Allergy and Asthma Reports·Elise CoulsonCem Akin
Jan 17, 2020·International Journal of Molecular Sciences·Gilda Varricchi, Gianni Marone
Apr 26, 2021·The Journal of Allergy and Clinical Immunology·Charles F SchulerCem Akin
Sep 26, 2021·Pediatric Dermatology·Aysegul ErtugrulIlknur Bostanci

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