PMID: 16515464Mar 7, 2006Paper

New insights into endocannabinoid degradation and its therapeutic potential

Mini Reviews in Medicinal Chemistry
Monica BariM Maccarrone

Abstract

Endocannabinoids are amides, esters and ethers of long chain polyunsaturated fatty acids, which act as new lipidic mediators. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol (2-AG) are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of (-)-Delta9-tetrahydrocannabinol (THC), the active principle of Cannabis sativa preparations like hashish and marijuana. The activity of AEA and 2-AG at their receptors is limited by cellular uptake through an anandamide membrane transporter (AMT), followed by intracellular degradation. A fatty acid amide hydrolase (FAAH) is the main AEA hydrolase, whereas a monoacylglycerol lipase (MAGL) is critical in degrading 2-AG. Here, we will review growing evidence that demonstrates that these hydrolases are pivotal regulators of the endogenous levels of AEA and 2-AG in vivo, overall suggesting that specific inhibitors of AMT, FAAH or MAGL may serve as attractive therapeutic targets for the treatment of human disorders. Recently, the N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD), which synthesizes AEA from N-arachidonoylphosphatidylethanolamine (NArPE), and the diacylglycerol lipase (DAGL), which generates 2-A...Continue Reading

Citations

Sep 30, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maria Valeria CataniMauro Maccarrone
Nov 16, 2007·European Journal of Clinical Pharmacology·Cristiana RossiPaola Sarchielli
Oct 5, 2007·Current Psychiatry Reports·David R Janero, Alexandros Makriyannis
Mar 14, 2007·Current Opinion in Lipidology·Aaron Z Fernandis, Markus R Wenk
Sep 10, 2010·Lipids in Health and Disease·Massimo CocchiGiovanni Lercker
Oct 20, 2012·PloS One·Sheena E M LewisMauro Maccarrone
Aug 1, 2008·Future Lipidology·Kasem Nithipatikom, William B Campbell
May 23, 2014·Trends in Pharmacological Sciences·Daniel J HermansonSachin Patel
Oct 24, 2007·Molecular Neurobiology·María Gómez-RuizJose A Ramos
Jan 21, 2014·Molecular Neurobiology·Maria Teresa Viscomi, Marco Molinari
May 6, 2014·European Child & Adolescent Psychiatry·Daniela CalvigioniErik Keimpema
Nov 26, 2009·Cellular and Molecular Life Sciences : CMLS·Maria Valeria CataniMauro Maccarrone
Jan 9, 2013·Expert Opinion on Therapeutic Targets·Ioanna VasileiouStamatios Theocharis
May 6, 2015·Expert Opinion on Therapeutic Targets·Demetrios MorisStamatios Theocharis
Dec 21, 2010·Prostaglandins & Other Lipid Mediators·Kasem NithipatikomWilliam B Campbell
Apr 1, 2010·Experimental Neurology·M T ViscomiM Molinari
Aug 15, 2009·Biochemical and Biophysical Research Communications·Giuseppina CatanzaroMauro Maccarrone
Jul 16, 2009·Progress in Lipid Research·Mauro Maccarrone
Sep 11, 2008·Bioorganic & Medicinal Chemistry·Carla FerreriAthanassia Siafaka-Kapadai
Jul 4, 2008·Experimental Eye Research·Ya Fatou NjieZhao-Hui Song
Sep 11, 2007·Bioorganic & Medicinal Chemistry Letters·Subramanian K VadivelAlexandros Makriyannis
Mar 14, 2007·Trends in Pharmacological Sciences·Diego CentonzeMauro Maccarrone
Sep 11, 2007·British Journal of Pharmacology·M Maccarrone
Apr 20, 2007·International Journal of Cancer. Journal International Du Cancer·Michael P EndsleyKasem Nithipatikom
Aug 23, 2007·Chemistry & Biodiversity·Kazuhito TsuboiNatsuo Ueda
May 9, 2008·Journal of Neuroendocrinology·L BellocchioU Pagotto
Jan 3, 2013·Fundamental & Clinical Pharmacology·Panagiotis ZogopoulosStamatios E Theocharis
Feb 18, 2011·Journal of Cellular Biochemistry·Maria Grazia SignorelloGiuliana Leoncini
Jan 9, 2013·Journal of Applied Toxicology : JAT·Panagiotis ZogopoulosStamatios Theocharis
Jul 21, 2007·Neural Plasticity·María-Paz ViverosMeritxell López-Gallardo
Apr 29, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Antonia ManducaViviana Trezza
Jul 10, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·JodiAnne T WoodCarol J Lammi-Keefe
Aug 24, 2007·Neuropharmacology·Monica BariMauro Maccarrone
Jun 22, 2016·Neurotoxicology and Teratology·Iram P Rodriguez-SanchezNatalia E Schlabritz-Loutsevitch
Aug 7, 2007·International Review of Neurobiology·Sergio OddiMauro Maccarrone
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Louk J M J VanderschurenViviana Trezza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Drug Targets. CNS and Neurological Disorders
Alessia LigrestiV Di Marzo
Annual Review of Biochemistry
Michele K McKinney, Benjamin F Cravatt
Proceedings of the National Academy of Sciences of the United States of America
Thien P DinhD Piomelli
© 2021 Meta ULC. All rights reserved