Nov 21, 2012

New insights into establishment and maintenance of DNA methylation imprints in mammals

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Gavin Kelsey, Robert Feil

Abstract

Fundamental to genomic imprinting in mammals is the acquisition of epigenetic marks that differ in male and female gametes at 'imprinting control regions' (ICRs). These marks mediate the allelic expression of imprinted genes in the offspring. Much has been learnt about the nature of imprint marks, the times during gametogenesis at which they are laid down and some of the factors responsible especially for DNA methylation. Recent work has revealed that transcription and histone modifications are critically involved in DNA methylation acquisition, and these findings allow us to propose rational models for methylation establishment. A completely novel perspective on gametic DNA methylation has emerged from epigenomic profiling. Far more differentially methylated loci have been identified in gametes than known imprinted genes, which leads us to revise the notion that methylation of ICRs is a specifically targeted process. Instead, it seems to obey default processes in germ cells, giving rise to distinct patterns of DNA methylation in sperm and oocytes. This new insight, together with the identification of proteins that preserve DNA methylation after fertilization, emphasizes the key role played by mechanisms that selectively retain...Continue Reading

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  • Citations62

Citations

Mentioned in this Paper

DNA Methylation [PE]
Ovum
Protein Methylation
Transcription, Genetic
Methylate
DNA Methylation
Maintenance of DNA Methylation
Study of Epigenetics
Gametes
Methylation

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