New insights into long non-coding RNAs in non-small cell lung cancer.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Ruifang YeYanqin Sun


Lung cancer is a malignant tumor that seriously threatens human life and health. Non-small cell lung cancer (NSCLC) accounts for 85 % of all lung cancer cases, and its global 5-year survival rate is only approximately 5%. Thus, the identification of new prognostic biomarkers has become one of the most urgent challenges in NSCLC research. Long noncoding RNAs (LncRNAs) are a kind of noncoding RNA whose length exceeds 200 nucleotides (nt). LncRNAs are transcribed by RNA pol II and can be subjected to posttranscriptional modifications such as blocking, polyadenylation and splicing; moreover, their expression profiles are more specific than those of mRNAs. Emerging evidence confirms that lncRNAs are associated with the occurrence and development of NSCLC and play an important role in NSCLC drug resistance. The purpose of this review was to describe the roles of lncRNAs in the development, diagnosis and prognosis of NSCLC and to explore new evidence of lncRNAs in the treatment of NSCLC drug resistance. This review provides a new perspective of lncRNAs in the treatment of NSCLC.


May 15, 2021·Journal of Cellular and Molecular Medicine·Liwei WuLin Wang
Jun 18, 2021·Frontiers in Molecular Biosciences·Lanxiang HuangFubing Wang
Jul 18, 2021·Seminars in Cancer Biology·Faizan Haider KhanAta Abbas
Nov 28, 2021·International Journal of Molecular Sciences·Sarah Sayed HassaneinAhmed Lotfy Abdel-Mawgood
Dec 22, 2021·DNA and Cell Biology·Hossein Ghahramani AlmanghadimSaman Sargazi

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