New insights into no-go, non-stop and nonsense-mediated mRNA decay complexes.

Current Opinion in Structural Biology
Kyle T PowersChristiane Schaffitzel

Abstract

Eukaryotes possess a variety of translational control mechanisms which function in the surveillance of mRNAs, discriminating between normal and aberrant translation elongation and termination, triggering mRNA decay. The three major evolutionarily conserved eukaryotic pathways are No-Go, Non-Stop and Nonsense-Mediated mRNA Decay. Recent findings suggest that stalling of the ribosome, due to mRNA secondary structure or translation into poly(A)-stretches, leads to ribosome collisions which are detected by No-Go/Non-Stop mRNA decay factors. Subsequent ribosome ubiquitination at the interface of two collided ribosomes is considered the signal for mRNA decay. Similarly, translation termination at a premature stop codon is slower than normal, leading to recruitment and activation of nonsense-mediated mRNA decay factors, including SMG1-8-9. Here, we detail new insights into the molecular mechanisms of these pathways.

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Citations

Dec 3, 2020·Nucleic Acids Research·Sylvain de BreyneThéophile Ohlmann
Nov 17, 2020·European Journal of Medicinal Chemistry·Margarida D Amaral
Apr 17, 2021·Trends in Immunology·Taishin AkiyamaTadashi Yamamoto
May 6, 2021·Wiley Interdisciplinary Reviews. RNA·Christelle MorrisEmiliano P Ricci
Aug 6, 2021·Frontiers in Immunology·Taishin Akiyama, Tadashi Yamamoto
Sep 1, 2021·Wiley Interdisciplinary Reviews. RNA·Alyssa M EnglishStephanie L Moon

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