Oct 4, 2016

New insights into old worm proteomes

Worm
Stephanie M Zimmerman, Stuart K Kim

Abstract

Aging is accompanied by large-scale changes in the proteome, which could have important consequences for cellular and organismal physiology. In this commentary, we review recent studies characterizing the aging proteome in C. elegans. We assess the evidence that the rates of protein synthesis, folding, and degradation change with age in C. elegans, and evaluate whether changes in these pathways limit normal lifespan. We also discuss large-scale studies measuring changes in the proteome with age that suggest that a failure to excrete reproductive proteins in post-reproductive animals plays a role in changing protein levels with age.

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Mentioned in this Paper

Calcinus elegans
Cyartonema elegans
Study
Coleonyx elegans
Biochemical Pathway
Cestrum elegans
Clarkia unguiculata
Clathrulina elegans
Cardioglossa elegans
Cymbella elegans

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