New insights into phylogeography of worldwide Brucella canis isolates by comparative genomics-based approaches: focus on Brazil

BMC Genomics
Acácia Ferreira VicenteVirginie Mick

Abstract

Canine brucellosis, due to Brucella canis, is a worldwide zoonosis that remains endemic in South America, including Brazil. Implementation of powerful whole-genome sequencing approaches allowed exploring the Brucella genus considered as monomorphic, with, to date, more than 500 genomes available in public databases. Nevertheless, with under-representation of B. canis genomes -only twenty complete or draft genomes-, lack of knowledge about this species is still considerable. This report describes a comparative genomics-based phylogeographic investigation of 53 B. canis strains, including 28 isolates paired-end sequenced in this work. Obtained results allow identifying a SNP panel species-specific to B. canis of 1086 nucleotides. In addition, high-resolution analyses assess the epidemiological relationship between worldwide isolates. Our findings show worldwide strains are distributed among 2 distinct lineages. One of them seems to be specific to South American strains, including Brazil. B. canis South American strains may be identified by a SNP panel of 15 nucleotides, whereas a 22 SNP panel is sufficient to define contamination origin from Brazil. These results lead to the proposal of a possible spread route for dog brucellosis...Continue Reading

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Citations

Dec 12, 2018·Microbiology Resource Announcements·Guillaume GiraultVirginie Mick

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Datasets Mentioned

BETA
CP007759.1
ERR2136548
ERR2136549

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

MLVA Analysis−
BioNumerics
MLST Typing−
Trimmomatic
ART

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