New insights into redox regulation of stem cell self-renewal and differentiation

Biochimica Et Biophysica Acta
Fenglian RenCanhua Huang

Abstract

Reactive oxygen species (ROS), the natural byproducts of aerobic metabolism, are precisely orchestrated to evoke diverse signaling pathways. To date, studies have focused mainly on the detrimental effects of ROS in stem cells. Recently, accumulating evidence has suggested that ROS also function as second messengers that modulate stem cell self-renewal and differentiation by regulating intricate signaling networks. Although many efforts have been made to clarify the general effects of ROS on signal transduction in stem cells, less is known about the initial and direct executors of ROS signaling, which are known as 'redox sensors'. Modifications of cysteine residues in redox sensors are of significant importance in the modulation of protein function in response to different redox conditions. Intriguingly, most key molecules in ROS signaling and cell cycle regulation (including transcriptional factors and kinases) that are crucial in the regulation of stem cell self-renewal and differentiation have the potential to be redox sensors. We highlight herein the importance of redox regulation of these key regulators in stem cell self-renewal and differentiation. Understanding the mechanisms of redox regulation in stem cell self-renewal ...Continue Reading

References

Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·J SmithM Noble
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·H S ParkE J Choi
Mar 28, 2002·The Journal of Biological Chemistry·Seung-Rock LeeSue Goo Rhee
Apr 2, 2002·The Journal of Biological Chemistry·Pavel A Savitsky, Toren Finkel
Sep 6, 2002·The Journal of Biological Chemistry·Takeyuki NishiHiroshi Handa
Oct 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Young R SeoMartin L Smith
Jan 9, 2003·Structure·Xin HuangXiaotian Zhu
Jul 2, 2003·EMBO Reports·Maddalena Donzelli, Giulio F Draetta
Oct 3, 2003·The Journal of Biological Chemistry·Hiroaki MurataTakahito Kondo
Oct 29, 2003·Antioxidants & Redox Signaling·Xiu Zhu SunJamil Momand
Feb 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nobunao WakabayashiPaul Talalay
Nov 9, 2004·Current Opinion in Cell Biology·Anna V MolofskySean J Morrison
Dec 16, 2005·Molecular and Cellular Biology·Akira KobayashiMasayuki Yamamoto
Jun 23, 2006·The Journal of Biological Chemistry·Wenge LiA-N Tony Kong
Dec 21, 2006·The Journal of Biological Chemistry·Han QinHongkui Deng
Mar 27, 2007·Free Radical Biology & Medicine·Sharon Lim, Marie-Véronique Clément
Apr 12, 2007·The Journal of Biological Chemistry·Yong XuDaret K St Clair
Jan 19, 2008·Nature Reviews. Genetics·Keith W Orford, David T Scadden
Mar 29, 2008·Cell Stem Cell·Kana MiyamotoAtsushi Hirao
Mar 29, 2008·Cell Stem Cell·Zuzana Tothova, D Gary Gilliland
Jul 17, 2008·Antioxidants & Redox Signaling·Kazuhito NakaAtsushi Hirao
Jul 31, 2008·Antioxidants & Redox Signaling·Laura S Haneline
Nov 4, 2008·Antioxidants & Redox Signaling·Gianluca TellMark R Kelley
Jan 9, 2009·Cell Stem Cell·Yan LiuStephen D Nimer
Jun 3, 2009·Free Radical Biology & Medicine·William C Burhans, Nicholas H Heintz

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Citations

Mar 21, 2015·Biochimica Et Biophysica Acta·Carsten Berndt, Christopher Horst Lillig
Feb 6, 2018·Journal of Cell Communication and Signaling·Martien van WenumRuurdtje Hoekstra
Oct 9, 2015·American Journal of Physiology. Cell Physiology·Ying-Jie Wang, Meenhard Herlyn
May 3, 2019·Oxidative Medicine and Cellular Longevity·Ying LiIhn Han
Apr 24, 2019·Analytical and Bioanalytical Chemistry·Marco MalferrariStefania Rapino
Nov 9, 2018·Antioxidants·Christine RamponSophie Vriz
Mar 7, 2021·Cancers·Marinella MarzanoMariangela De Robertis
Mar 9, 2021·Free Radical Biology & Medicine·Emmy Xue Yun TayDerrick Sek Tong Ong
Mar 16, 2021·Dose-response : a Publication of International Hormesis Society·Yue HuangNaiyao Chen

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