New insights into salivary lactate dehydrogenase of human subjects

The Journal of Laboratory and Clinical Medicine
R NaglerAbraham Z Reznick

Abstract

Lactate dehydrogenase (LDH) is a ubiquitous enzyme that plays a significant role in the clinical diagnosis of pathologic processes. The purpose of the current study was to examine LDH activity and isoenzyme profile of whole saliva and to compare it with the LDH activity of salivary glands and plasma before and after exposure to cigarette smoke (CS). The range of LDH activity in whole saliva at rest was 360 to 430 U/L. The mean +/- SEM of LDH activity in parotid and submandibular/sublingual salivary secretions was 41.3 +/- 19.2 U/L and 77.5 +/- 30.4 U/L, respectively, which implied that 75% of the whole-saliva LDH originated from an extra-salivary gland source. The profile of salivary LDH isoenzymes was found to have an entirely different pattern from that found in plasma, similar to that found in oral epithelium, indicating that the major source of salivary LDH is probably the oral epithelium-shedding cells. Therefore, salivary LDH may be evaluated for possible oral mucosal pathologies in a manner similar to that used for evaluating other tissue pathologies--such as those in heart, muscle, or liver--that can be detected in plasma. Exposure of whole saliva to CS in vitro resulted in a 41% reduction in LDH activity. However, CS e...Continue Reading

Citations

Jul 12, 2007·European Journal of Clinical Nutrition·T BlazerR M Nagler
Jan 12, 2008·Blood Purification·Regina MichelisRafael M Nagler
Jan 12, 2010·Molecular Medicine·Riva BrikRafael Nagler
Sep 21, 2013·Biomarkers in Medicine·Eran FrontRafael M Nagler
Apr 5, 2008·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Guy BibiRafael M Nagler
Jun 1, 2007·The Journal of Toxicological Sciences·Nobuhiro GoiKuniaki Takagi
Jul 15, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Oded HershkovichRafael M Nagler
Nov 29, 2016·Medicine·Barbara MalickaUrszula Kaczmarek
May 5, 2007·Journal of Cancer Research and Clinical Oncology·Thomas ShpitzerRafael M Nagler
Jan 30, 2008·The Journal of Obstetrics and Gynaecology Research·Tomoko KugaharaKazutomo Ohashi
Aug 7, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G LivnatR M Nagler
Aug 4, 2010·European Journal of Clinical Investigation·Yehuda UllmannRafael Nagler
May 27, 2004·British Journal of Cancer·A Z ReznickR M Nagler
Jan 16, 2007·Journal of Oral Science·Yoshiaki NomuraKyuichi Kamoi
Jan 6, 2006·Aging Clinical and Experimental Research·Rafael M Nagler, Oded Hershkovich
Sep 17, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M SivaramakrishnanM Jananni
Nov 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tajindra Singh SalujaShaheen Syed
Apr 23, 2020·Journal of Family Medicine and Primary Care·Abhilasha S PatilShantanu B Pharande
Oct 30, 2019·Anti-cancer Agents in Medicinal Chemistry·Nooshin MohtashamFarnaz Mohajertehran
Aug 13, 2020·Metabolites·Marco MeletiThelma A Pertinhez
Sep 1, 2009·The Journal of Physical Chemistry. B·Katarzyna SwiderekPiotr Paneth
Feb 7, 2012·Journal of Agricultural and Food Chemistry·Pinar Omür-ÖzbekYongWoo Lee
Apr 30, 2011·The Journal of Physical Chemistry. B·Katarzyna Świderek, Piotr Paneth

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