New insights into systemic sclerosis related microcirculatory dysfunction by assessment of sublingual micr\ocirculation and vascular glycocalyx layer. Results from a preliminary study

Microvascular Research
S MirandaY Benhamou

Abstract

Initial morphological and functional markers of systemic sclerosis (SSc) are evidenced in microvascular structural damage. However, nailfold videocapillaroscopy (NVC) explores only morphological abnormalities. Sidestream Dark Field (SDF) imaging of sublingual microcirculation enables assessment of both morphological and functional capillary impairment and allows measurement of the glycocalyx layer, which is an indicator of endothelial dysfunction. To describe and validate sublingual abnormalities assessed by SDF device in comparison with NVC findings and to measure the thickness of the glycocalyx layer. From February to May 2014, 26 subjects (16 SSc patients and 10 healthy controls) underwent standardised NVC and SDF imaging of sublingual microcirculation. Glycocalyx thickness was also measured. Capillary density and percentage of perfused vessels were significantly reduced in patients with SSc (n = 13) compared to controls. Correlation between nailfold capillary density assessed by NVC and sublingual capillary density assessed by SDF was observed (r(2) = 0.59; P = 0.023). According to the NVC pattern, patients with "active" disease experienced greater reduction in capillary density than patients with "late" disease as suggeste...Continue Reading

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Citations

Jan 13, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Didem SayginAdriano R Tonelli
Jun 24, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·George A MashourRaj C Shah
Sep 6, 2017·Current Rheumatology Reports·Salma SiddiqueStéphane Zuily
Sep 25, 2018·Frontiers in Immunology·Cosimo BruniSilvia Bellando-Randone
May 22, 2019·Current Opinion in Pharmacology·Daniel R MachinAnthony J Donato
Aug 18, 2021·Current Opinion in Rheumatology·Nicholas A Flavahan

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