New insights into the biology of filarial infections

Journal of Helminthology
Sabine Specht, S Wanji

Abstract

Recent successes in the control of lymphatic filariasis and onchocerciasis need continuing research in order to sustain the achievements and to develop further tools to tackle the new questions that arise when only reduced infection prevalences prevail. In this regard, in a symposium held at the Xth European Multicolloquium of Parasitology (August 2008, Paris) questions such as the impact of filarial immunosuppression, and its lack following filarial control, on the outcome of co-infections were addressed, as were new approaches to treatment with promising drugs such as moxidectin or the antibiotic chemotherapy against Wolbachia endosymbionts in filariae. In particular, longer treatment courses of doxycycline could be carried out by community-directed treatment at high coverage, thus potentially allowing its use in restricted areas with suboptimal responses to ivermectin against onchocerciasis, or in areas with co-infection by loiasis where onchocerciasis or lymphatic filariasis need to be controlled. New, more potent drugs, or eventually vaccines, will be of importance because in many vector-filarial parasite relationships worldwide, transmission efficacy increases with low numbers of ingested microfilariae, and since ivermect...Continue Reading

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Citations

Feb 23, 2013·Expert Opinion on Drug Delivery·Mohammad AliAmit Kumar Dinda
Jul 26, 2011·International Journal for Parasitology·Elena MelnikowSara Lustigman
Nov 6, 2009·Dermatologic Therapy·Natalia MendozaStephen Tyring
May 8, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jiali CaiZhenghong Zuo
Jul 6, 2013·Reproduction in Domestic Animals = Zuchthygiene·S Arrighi, M Aralla
Mar 22, 2014·Biology of Reproduction·Winnie W ShumNicolas Da Silva
Apr 11, 2014·Biology of Reproduction·Andrew D WestmuckettKevin L Moore

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