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New insights into the control of stem cell pluripotency

Cell Stem Cell

Mar 29, 2008

Paul J Gokhale, Peter W Andrews

Abstract

Nanog is a transcription factor that is expressed by mouse and human embryonic stem (ES) cells and by primordial germ cells. New research published recently in Nature (Chambers et al., 2007) points to an unexpected role for Nanog in the maintenance of pluripotency in mouse ES cells.

Mentioned in this Paper

Embryo
Pluripotent Stem Cells
Nanog Homeobox Protein
SOX2 protein, human
Feeder Cells
Cell Differentiation Process
Oct3A protein, human
Germ Cells
Homeodomain Proteins
NANOG protein, human
Paper Details
References
  • References5
  • Citations2
1

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New insights into the control of stem cell pluripotency

Cell Stem Cell

Mar 29, 2008

Paul J Gokhale, Peter W Andrews

PMID: 18371412

DOI: 10.1016/j.stem.2007.12.007

Abstract

Nanog is a transcription factor that is expressed by mouse and human embryonic stem (ES) cells and by primordial germ cells. New research published recently in Nature (Chambers et al., 2007) points to an unexpected role for Nanog in the maintenance of pluripotency in mouse ES cells.

Mentioned in this Paper

Embryo
Pluripotent Stem Cells
Nanog Homeobox Protein
SOX2 protein, human
Feeder Cells
Cell Differentiation Process
Oct3A protein, human
Germ Cells
Homeodomain Proteins
NANOG protein, human

Similar Papers Found In These Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Induced Pluripotent Stem Cells

Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors, These cells have similar properties to those of embryonic stem cells (escs) but bypass the ethical concerns of embryo destruction and can be exploited for both research and clinical applications.Discover the latest research on iPSC here.

Related Papers

Journal of Assisted Reproduction and Genetics

Co-localization of NANOG and OCT4 in human pre-implantation embryos and in human embryonic stem cells

Journal of Assisted Reproduction and GeneticsJune 30, 2012
Fredwell HambilikiAnneli Stavreus-Evers
Cell Stem Cell

TGFbeta and SMADs talk to NANOG in human embryonic stem cells

Cell Stem CellAugust 7, 2008
Jianming Jiang, Huck-Hui Ng
Paper Details
References
  • References5
  • Citations2
1
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