New insights into the developing rabbit brain using diffusion tensor tractography and generalized q-sampling MRI

PloS One
Seong Yong LimJun-Cheng Weng

Abstract

The use of modern neuroimaging methods to characterize the complex anatomy of brain development at different stages reveals an enormous wealth of information in understanding this highly ordered process and provides clues to detect neurological and neurobehavioral disorders that have their origin in early structural and functional cerebral maturation. Non-invasive diffusion tensor magnetic resonance imaging (DTI) is able to distinguish cerebral microscopic structures, especially in the white matter regions. However, DTI is unable to resolve the complicated neural structure, i.e., the fiber crossing that is frequently observed during the maturation process. To overcome this limitation, several methods have been proposed. One such method, generalized q-sampling imaging (GQI), can be applied to a variety of datasets, including the single shell, multi-shell or grid sampling schemes that are believed to be able to resolve the complicated crossing fibers. Rabbits have been widely used for neurodevelopment research because they exhibit human-like timing of perinatal brain white matter maturation. Here, we present a longitudinal study using both DTI and GQI to demonstrate the changes in cerebral maturation of in vivo developing rabbit ...Continue Reading

References

Jun 1, 1996·Journal of Magnetic Resonance. Series B·P J Basser, C Pierpaoli
Apr 27, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A L AlexanderD L Parker
Sep 28, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David S TuchVan J Wedeen
Nov 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David S Tuch
Oct 26, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Van J WedeenRobert M Weisskoff
Jun 1, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alexander DrobyshevskySidhartha Tan
Jan 30, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark H KhachaturianDavid S Tuch
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·Matthew DerrickSidhartha Tan
May 8, 2007·NeuroImage·Yu-Chien Wu, Andrew L Alexander
Oct 27, 2007·Developmental Neuroscience·Helen D'ArceuilAlex de Crespigny
Oct 11, 2008·American Journal of Obstetrics and Gynecology·Fadoua Saadani-MakkiDiane Chugani
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Masaki FukunagaJeff H Duyn
Mar 23, 2010·IEEE Transactions on Medical Imaging·Fang-Cheng YehWen-Yih Isaac Tseng

❮ Previous
Next ❯

Software Mentioned

DSI Studio
GQI

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.