New insights into the diversity and function of neuronal immunoglobulin superfamily molecules

Annual Review of Neuroscience
Genevieve Rougon, Oliver Hobert

Abstract

Immunoglobulin superfamily (IgSF) proteins are implicated in diverse steps of brain development, including neuronal migration, axon pathfinding, target recognition and synapse formation, as well as in the maintenance and function of neuronal networks in the adult. We provide here a review of recent findings on the diversity and the role of transmembrane and secreted members of IgSF proteins in the nervous system. We illustrate that the complexity of IgSF protein function results from various different levels of regulation including regulation of gene expression, protein localization, and protein interactions.

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Methods Mentioned

BETA
myristoylation
GTPases
nucleotide exchange
GTPase
nucleotide
transgenic
imaging techniques

Software Mentioned

BLAST
Robo

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