Abstract
1) To develop an in vitro system to simulate the kinetics of ionized calcium in mixed venous blood during rapid transfusion of fresh frozen plasma (FFP) and 2) to use the in vitro data to estimate the effect of the transfusion rate relative to cardiac output (CO) on ionized calcium. Experimental study. Research laboratory of an academic hospital. Citrated FFP was mixed with compatible heparinized whole blood at various volume ratios in vitro to simulate the mixed venous blood obtained at various flow ratios of FFP transfusion to the recipient's venous system in vivo. Ionized calcium was measured after each mixture. Mixing FFP and whole blood at volume ratios of 0:100, 5:95, 10:90, and 15:85 yielded ionized calcium levels (mean ± SD, mmol/L) of 1.23, 0.81 ± 0.02, 0.54 ± 0.08, and 0.34 ± 0.02, respectively. The 50% reduction in ionized calcium occurred at a volume ratio of 7:93. An instantaneous 50% reduction in ionized calcium occurs in vitro at a proportion equivalent to a transfusion rate of FFP representing 7% of CO.
References
Nov 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·L J DropP M Stulz
Oct 1, 1976·British Journal of Anaesthesia·J K DenlingerJ H Lecky
Aug 1, 1976·The Laryngoscope·R N MillerJ H Landenson
Feb 1, 1985·The Journal of General Physiology·A Fabiato
Feb 1, 1985·The Journal of General Physiology·A Fabiato
Apr 1, 1985·Anesthesia and Analgesia·L J Drop
Feb 1, 1985·The Journal of General Physiology·A Fabiato
Jan 1, 1985·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·L DumontC Chartrand
Dec 1, 1971·British Journal of Anaesthesia·J E Hinkle, L H Cooperman
Jul 1, 1966·Anesthesiology·J P Bunker
Aug 1, 1983·British Journal of Anaesthesia·T R Abbott
Jul 1, 1983·Cardiovascular Research·G A GeffinW M Daggett
Apr 1, 1981·Critical Care Medicine·B A McKinleyD R Westenskow
May 1, 1981·The American Journal of Cardiology·L J DropW M Daggett
Sep 1, 1980·Canadian Anaesthetists' Society Journal·J K HayesD R Westenskow
Sep 1, 1996·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·V L ScottB M Altura
Feb 22, 1962·The New England Journal of Medicine·J P BUNKERA J MURPHY
Aug 20, 2005·Clinical Biochemistry·Jocelyne CousineauEdgard E Delvin
Oct 2, 2007·Transfusion Medicine·W H Dzik
Aug 22, 2009·Blood Reviews·Philip C Spinella, John B Holcomb
Citations
Mar 21, 2013·The Journal of Surgical Research·S Said KökçamYusuf Küçükbağriaçik
Jan 10, 2021·The American Journal of Emergency Medicine·Jesse P WrayBrit Long
Mar 2, 2021·Anesthesia and Analgesia·Phuriphong ChanthimaJohn R Hess