New insights into the function of IAP proteins: modulation of the MYC/MAX/MAD network

Developmental Cell
Casey W Wright, Colin S Duckett

Abstract

A growing number of studies have revealed that the inhibitor of apoptosis (IAP) proteins play a variety of cellular roles in addition to suppression of apoptosis. A recent study in Molecular Cell demonstrates that one IAP member, c-IAP1, functions to potentiate the activity of Myc by triggering the ubiquitination and proteasomal degradation of the Myc inhibitory protein Mad1.

Citations

Jul 15, 2018·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Xiang ZhuWubei Dong

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