PMID: 9420471Jan 1, 1997Paper

New insights into the genomic organization and origin of the major histocompatibility complex: role of chromosomal (genome) duplication in the emergence of the adaptive immune system

Hereditas
M Kasahara

Abstract

Recently, it became clear that the human and mouse genomes contain at least three regions paralogous to the major histocompatibility complex (MHC) region. This observation led us to the proposal that the MHC region emerged as a result of chromosomal duplication that took place at an early stage of vertebrate evolution. Here I briefly review this proposal. Accumulating evidence indicates that (a) genome-wide duplication(s) took place close to the origins of vertebrates. Taking this and others into account, I suggest that the duplication(s) involving the MHC region probably took place as a part of the genome-wide duplication(s). The human T cell receptor (TCR) and immunoglobulin (Ig) genes also appear to be located on paralogous chromosomal segments. These findings raise the possibility that the genome-wide duplication provided a major impetus not only to the emergence of the full-fledged MHC system, but also to the appearance of other key molecules of the adaptive immune system such as TCR and Ig.

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Citations

Mar 29, 2002·European Journal of Immunology·Michelle S TengJohn Trowsdale
Jan 20, 2009·Molecular Biology and Evolution·Narayanan Raghupathy, Dannie Durand
Jul 12, 2017·Immunogenetics·Anthony B Wilson
Nov 10, 2001·Annual Review of Genomics and Human Genetics·S Beck, J Trowsdale
Oct 26, 2005·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Rose HobermanDannie Durand
Jan 28, 2014·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Nil Ratan SahaChris T Amemiya
Jul 27, 2017·Biological Reviews of the Cambridge Philosophical Society·Viktor MüllerEörs Szathmáry
Sep 8, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko OhtaMartin F Flajnik
Dec 7, 2000·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·K ChenM Farach-Colton
Aug 26, 2003·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Dannie Durand, David Sankoff
May 21, 2010·European Journal of Immunology·Zuly E ParraRobert D Miller
Aug 19, 2015·Immunological Reviews·Jim Kaufman
Jun 21, 2016·Immunological Reviews·Vincent F VartabedianLuc Teyton
Dec 12, 2012·Immunogenetics·Kentaro TsukamotoKeiichiro Hashimoto
Feb 27, 1999·Current Opinion in Immunology·K Früh, Y Yang
Aug 1, 1998·Trends in Ecology & Evolution·S V Edwards, P W Hedrick
Jan 23, 1999·Current Opinion in Genetics & Development·L Skrabanek, K H Wolfe

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