New Insights into the Immune Molecular Regulation of the Pathogenesis of Acute Respiratory Distress Syndrome

International Journal of Molecular Sciences
Chin-Yao YangChia-Jung Li

Abstract

Acute respiratory distress syndrome is an inflammatory disease characterized by dysfunction of pulmonary epithelial and capillary endothelial cells, infiltration of alveolar macrophages and neutrophils, cell apoptosis, necroptosis, NETosis, and fibrosis. Inflammatory responses have key effects on every phase of acute respiratory distress syndrome. The severe inflammatory cascades impaired the regulation of vascular endothelial barrier and vascular permeability. Therefore, understanding the relationship between the molecular regulation of immune cells and the pulmonary microenvironment is critical for disease management. This article reviews the current clinical and basic research on the pathogenesis of acute respiratory distress syndrome, including information on the microenvironment, vascular endothelial barrier and immune mechanisms, to offer a strong foundation for developing therapeutic interventions.

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Citations

May 31, 2020·International Journal of Molecular Sciences·Isabella OrientiGiovanna Farruggia
Aug 22, 2018·Journal of Clinical Medicine·Meng-Yu WuChia-Jung Li
Mar 27, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shu-Nan CuiYou Shang
Apr 19, 2019·Journal of Clinical Medicine·Chia-Jung LiMeng-Yu Wu
Jul 28, 2020·Biomedicines·Chuan-Mu ChenWei Chen
Jan 1, 2021·Frontiers in Cell and Developmental Biology·Amanda KrajnikYongho Bae
Aug 3, 2020·Life Sciences·Gerwyn MorrisMichael Berk
Jul 28, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·João BessaTeresa Sousa
Apr 4, 2021·International Journal of Molecular Sciences·Barbara RuaroMarco Confalonieri
Oct 24, 2020·Life Sciences·Gerwyn MorrisMichael Berk
Jul 13, 2021·Physiological Reports·Martin StenloSandra Lindstedt
Jul 24, 2021·International Immunopharmacology·Zu-An ShiYong Wan
Oct 1, 2021·Molecular Medicine Reports·Xianjun WangYanli Wang

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Methods Mentioned

BETA
bronchoalveolar
bronchoalveolar lavage
GTPases
sedation

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