New insights into the mechanism of dynein motor regulation by lissencephaly-1.

ELife
Steven M MarkusRichard J McKenney

Abstract

Lissencephaly ('smooth brain') is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease - lissencephaly-1 (LIS1) - has been a focus of intense scrutiny since its first identification almost 30 years ago. LIS1 is a critical regulator of the microtubule motor cytoplasmic dynein, which transports numerous cargoes throughout the cell, and is a key effector of nuclear and neuronal transport during brain development. Here, we review the role of LIS1 in cellular dynein function and discuss recent key findings that have revealed a new mechanism by which this molecule influences dynein-mediated transport. In addition to reconciling prior observations with this new model for LIS1 function, we also discuss phylogenetic data that suggest that LIS1 may have coevolved with an autoinhibitory mode of cytoplasmic dynein regulation.

References

Dec 1, 1975·Genetical Research·N R Morris
Dec 1, 1995·The Journal of Biological Chemistry·S Karki, E L Holzbaur
Dec 15, 1993·JAMA : the Journal of the American Medical Association·W B DobynsD H Ledbetter
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·X XiangN R Morris
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y Y LiK Bloom
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D EshelI R Gibbons
Nov 1, 2000·Nature Cell Biology·N E FaulknerR B Vallee
Dec 21, 2000·The Journal of Cell Biology·R A Heil-ChapdelaineJ A Cooper
Jan 13, 2001·The Journal of Biological Chemistry·C Ahn, N R Morris
Jun 29, 2001·Mechanisms of Development·C Lambert de Rouvroit, A M Goffinet
Sep 22, 2001·The EMBO Journal·A StraubeG Steinberg
Jan 17, 2002·Cell·Davide SalinaBrian Burke
Mar 13, 2002·The Journal of Cell Biology·Chin-Yin TaiRichard B Vallee
Apr 10, 2002·Molecular and Cellular Biology·Frédéric M CoquelleOrly Reiner
Feb 5, 2003·The Journal of Cell Biology·Wei-Lih LeeJohn A Cooper
May 31, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wei YanGary D Clark

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Citations

Nov 17, 2020·Frontiers in Cell and Developmental Biology·Xin Xiang, Rongde Qiu
May 7, 2021·Annual Review of Biophysics·John T CantyAhmet Yildiz
May 26, 2021·Current Biology : CB·Jayne Aiken, Erika L F Holzbaur
Jul 30, 2021·Nature Communications·Adam R FentonErika L F Holzbaur
Aug 26, 2021·Molecular Biology of the Cell·Carlos M GuardiaJuan S Bonifacino

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Methods Mentioned

BETA
nuclear translocation
CLIP-170
motility assays

Software Mentioned

UCSF Chimera

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