New insights into the mechanism of fibroblast to myofibroblast transformation and associated pathologies

International Review of Cell and Molecular Biology
Mitchell A WatskyArnold Postlethwaite

Abstract

Myofibroblasts are a differentiated cell type essential for wound healing, participating in tissue remodeling following insult. Myofibroblasts are typically activated fibroblasts, although they can also be derived from other cell types, including epithelial cells, endothelial cells, and mononuclear cells. In most organ systems, cell signals initiated following tissue-specific insult or during the metastatic process lead to differentiation of fibroblasts or other precursor cells to the myofibroblast phenotype. In addition to their beneficial and necessary role in wound healing, myofibroblasts also contribute to a number of pathologies, primarily fibrotic processes and tumor invasiveness. This review explores both traditional and nontraditional concepts of myofibroblast differentiation in the cornea, skin, heart, and other tissues, as well as some of the pathologies associated with myofibroblast activities.

Citations

Oct 1, 2010·Cardiovascular Research·Esther E Creemers, Yigal M Pinto
Feb 13, 2016·Frontiers in Physiology·Shuang LiangDavid A Brenner
Aug 8, 2014·Frontiers in Pharmacology·Jun XuTatiana Kisseleva
Mar 17, 2016·Free Radical Research·Haruhiko SakiyamaKeiichiro Suzuki
Jan 27, 2015·Pulmonary Circulation·Vadim ShlyonskyFrédérique Mies
Nov 1, 2018·Molecular Biology of the Cell·Julia HauptEileen M Shore
Dec 25, 2012·Fibrogenesis & Tissue Repair·David A BrennerKojiro Taura
Apr 9, 2015·Clinical and Translational Medicine·Peter J Wermuth, Sergio A Jimenez
Nov 19, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ulla StumpfMartin Scholz
Apr 17, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Shan-Shan ZhangTian-You Ling
Jun 13, 2012·Biological & Pharmaceutical Bulletin·Liuzhe ZhangMitsunobu R Kano
Mar 2, 2018·Blood Advances·Shahrouz GhafooryJasimuddin Ahamed
Nov 14, 2019·Journal of Cell Science·Katsumi FumotoAkira Kikuchi
Apr 29, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuxia WangArya Mani
Apr 21, 2020·Inflammation and Regeneration·Masataka Kuwana
Jan 5, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Punnya V AngadiSeema Hallikerimath
Mar 15, 2011·Pflügers Archiv : European journal of physiology·Thomas K Borg, Troy A Baudino
Feb 3, 2011·Lung·Lina María Salazar, Ana Milena Herrera
Aug 28, 2021·International Journal of Molecular Sciences·Monica L Brown LobbinsArnold E Postlethwaite

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