New Insights into the Molecular Events of Mammalian Fertilization

Trends in Biochemical Sciences
Yuhkoh Satouh, Masahito Ikawa

Abstract

Currently, infertility affects ∼16% of couples worldwide. The causes are reported to involve both male and female factors, including fertilization failure between mature spermatozoa and eggs. However, the molecular mechanisms involved in each step of mammalian fertilization are yet to be fully elucidated. Although some of these steps can be rescued with assisted reproductive technologies, it is important to clarify the molecular mechanisms involved for the treatment and diagnosis of infertile couples. This review illustrates recent findings in mammalian fertilization, discovered by combining gene modification techniques with other new approaches, and aims to show how these findings will guide future research in mammalian fertilization.

Citations

Feb 18, 2020·Frontiers in Cell and Developmental Biology·Alaaeldin SalehMichail Nomikos
Apr 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yoshitaka FujiharaMasahito Ikawa
Nov 25, 2020·International Journal of Molecular Sciences·Junki KamiyaKenji Miyado
Apr 16, 2021·The Journal of Reproduction and Development·Ryosuke KanekoAtsushi Jinno-Oue

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