New insights into the morphological and hormonal characteristics of spermatogenic arrest

Andrologia
Anne-Laure BarbotinV Mitchell

Abstract

The reported sperm retrieval rate (SRR) in patients with nonobstructive azoospermia (NOA) due to spermatogenic arrest (SA) is highly variable in the literature. This discrepancy could be explained by the heterogeneity of testicular tissues. Surprisingly, even though inhibin B levels reflect directly Sertoli cell function; no studies have evaluated this parameter in SA. We aimed to clarify the morphological and biological profile in 158 men with SA. From the total population, patients whose seminiferous tubules diameter was below 165 µm have higher SRR (46.9% vs. 27.4%, p < 0.05), lower inhibin levels and a higher frequency of nonuniform SA (71.9% vs. 38.7%, p < 0.001). On multivariate analysis, patients with late SA and a history of cryptorchidism were positively associated with successful sperm extraction. Patients with successful SRR and uniform SA exhibited inhibin levels twofold lower than those with failed TESE (45 pg/ml vs. 95 pg/ml, p < 0.05), whereas FSH levels were similar in the two groups. In this study, we showed for the first time that the mean diameter of the seminiferous tubules may be of value in the diagnosis of SA. Our results suggest that inhibin levels could be useful in the management of NOA with SA, along ...Continue Reading

References

Sep 1, 1986·Journal of Andrology·L JohnsonW B Neaves
Sep 24, 1998·The Journal of Clinical Endocrinology and Metabolism·F H PierikR F Weber
Dec 4, 2003·Human Reproduction·L NegriP E Levi-Setti
Dec 22, 2004·BJU International·Tomomoto IshikawaMasato Fujisawa
Mar 27, 2007·The Journal of Urology·Ranjith Ramasamy, Peter N Schlegel
Jun 16, 2007·The Journal of Urology·Andrew J HungPeter N Schlegel
Apr 9, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·E HuygheUNKNOWN les membres du Comité d'andrologie de l'association française d'urologie (CCAFU)
Oct 31, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F MarcelliJ-M Rigot
Jul 14, 2010·Annales de pathologie·Geoffroy RobinValérie Mitchell
Sep 28, 2010·Gynécologie, obstétrique & fertilité·G RobinJ-M Rigot
Jun 21, 2011·The Journal of Urology·John W WeedinLarry I Lipshultz
Aug 4, 2011·Journal of Clinical Medicine Research·Ibrahim Fathi GhalayiniYazan Haddad
Dec 14, 2011·Asian Journal of Andrology·Gert R DohleNiels J van Casteren
Jan 20, 2015·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Mar 6, 2015·European Journal of Endocrinology·Anne-Laure BarbotinValerie Mitchell
Nov 12, 2016·Basic and Clinical Andrology·J PrasivoravongJ-M Rigot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.