New insights into the natural course of knee osteoarthritis: early regulation of cytokines and growth factors, with emphasis on sex-dependent angiogenesis and tissue remodeling. A pilot study

Osteoarthritis and Cartilage
Kalle KisandAgu O Tamm

Abstract

This study was conducted to identify cytokine profiles associated with radiographic phenotypes of knee osteoarthritis (rKOA) with a focus on early stage of the disease. The pilot population study involved 60 middle-aged patients (mean age 50 ± 7.3y.). Standardized weight-bearing anteroposterior and axial radiographs were used to assess rKOA severity in tibiofemoral (TFJ) of patellofemoral joint (PFJ) by grading system (grades 0-3). Luminex (xMAP®) technology was used to simultaneously assess 60 biomarkers (BMs). Several pathways of angiogenic (CXCL10/IP-10, FGF1/2, PDGF-AA/BB, ANG1, RANTES), tissue remodeling/fibrosis (MMP1/3, TIMP2/3/4, TGFβ), and fat tissue (leptin) BMs associated with rKOA severity already in very early phase (grade 1). We identified several sets of cytokines as key markers of early knee osteoarthritis (KOA) predicting radiographic features in logistic-regression models (AUC = 0.80-0.97). Marked sex-specificity of rKOA course was detected: upregulation of angiogenesis dominated in females, whereas the activation of tissue remodeling was dominant in males. Several of these shifts, e.g., decrease of CXCL10/IP-10, took place only in grade 1 KOA and disappeared or reversed in later stages. OA of different knee-j...Continue Reading

Citations

Sep 4, 2020·Signal Transduction and Targeted Therapy·Yangli XieLin Chen
Aug 19, 2020·Nature Reviews. Rheumatology·Yangli XieMoosa Mohammadi
Dec 31, 2019·Osteoarthritis and Cartilage·W E van Spil, I A Szilagyi
Mar 19, 2021·Bone Research·Yan HuJiacan Su
Sep 2, 2021·Nature Reviews. Rheumatology·Armaghan MahmoudianFrank P Luyten

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