PMID: 8939173Nov 1, 1996Paper

New insights into the pathogenesis of severe corticosteroid-dependent asthma

The Journal of Allergy and Clinical Immunology
B VrugtR Aalbers

Abstract

Severe asthma is characterized by persistent T-cell activation, as demonstrated in both peripheral blood and bronchial mucosa. Endobronchial biopsy specimens of patients with severe, corticosteroid-dependent asthma revealed increased expression of CD25+ on mucosal T cells. Increased immunoreactivity for IL-5 further supports the evidence that the inflammatory response is orchestrated by TH2-type T cells. Peripheral blood eosinophils and total serum IgE levels were increased in the absence of allergen and despite optimal treatment. The chemokine IL-8 may also be an aggravating factor in severe asthma; as well as being a potent chemotactic and activating factor for neutrophils, it may also be chemoattractant for eosinophils. We have recently detected increased levels of free IL-8 in the peripheral blood of patients with chronic severe asthma but not in healthy control subjects or in patients with mild asthma, even after allergen challenge. In patients with severe asthma there may be an imbalance between IL-8 production and the blocking capacity of IL-8 autoantibodies. Higher levels of IL-8 complexed to IgA autoantibody and increased numbers of activated T cells were also found in patients with unstable asthma compared with patien...Continue Reading

References

Jan 1, 1992·Acta geneticae medicae et gemellologiae·J L Hopper
Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
Mar 1, 1992·The American Review of Respiratory Disease·R DjukanovićS T Holgate
May 1, 1991·The Journal of Clinical Investigation·Q HamidP K Jeffery
Aug 1, 1990·The American Review of Respiratory Disease·R DjukanovićS T Holgate
Dec 1, 1990·The American Review of Respiratory Disease·M AzzawiA B Kay
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Oct 1, 1994·American Journal of Respiratory and Critical Care Medicine·C WalkerB Villiger
Mar 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Shute
Jan 1, 1993·The American Review of Respiratory Disease·R AalbersJ G de Monchy
Jan 1, 1960·Journal of Clinical Pathology·M S DUNNILL

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Citations

Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·R LouisR Djukanović
Aug 12, 1998·American Journal of Respiratory Cell and Molecular Biology·M A FiedlerJ M Stark
Nov 7, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M SilvestriF L M Ricciardolo
Aug 16, 2005·Veterinary Immunology and Immunopathology·D W HorohovS S Pourciau

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