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New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection

Frontiers in Pharmacology

Jan 10, 2018

Lorenza BellusciGrazia Chiellini

Abstract

3-Iodothyronamine (T1AM) is an endogenous high-affinity ligand of the trace amine-associated receptor 1 (TAAR1), detected in mammals in many organs, including the brain. Recent evidence indicates that pharmacological TAAR1 activation may offer a novel therapeutic option for the treatmen...read more

Mentioned in this Paper

Study
Immunofluorescence Assay
Biochemical Pathway
EPHB2
M Protein, multiple myeloma
Derivatives
AKT1
c-fos Genes
Streptomyces griseus protease 1
MAPK3 wt Allele
1
27
Paper Details
References
  • References83
  • Citations3
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  • References83
  • Citations3
1

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New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection

Frontiers in Pharmacology

Jan 10, 2018

Lorenza BellusciGrazia Chiellini

PMID: 29311919

DOI: 10.3389/fphar.2017.00905

Abstract

3-Iodothyronamine (T1AM) is an endogenous high-affinity ligand of the trace amine-associated receptor 1 (TAAR1), detected in mammals in many organs, including the brain. Recent evidence indicates that pharmacological TAAR1 activation may offer a novel therapeutic option for the treatmen...read more

Mentioned in this Paper

Study
Immunofluorescence Assay
Biochemical Pathway
EPHB2
M Protein, multiple myeloma
Derivatives
AKT1
c-fos Genes
Streptomyces griseus protease 1
MAPK3 wt Allele
1
27

Similar Papers Found In These Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Neurotoxicity, Inflammation & Neuroprotection

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest discoveries pertaining to neurotoxicity, inflammation and neuroprotection.

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Paper Details
References
  • References83
  • Citations3
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  • References83
  • Citations3
1
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