New Insights into the Role of Epithelial⁻Mesenchymal Transition during Aging

International Journal of Molecular Sciences
Francisco SantosBruno Bernardes de Jesus

Abstract

Epithelial⁻mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of EMT proteins in aged tissues support the involvement of EMT as a possible cause and/or consequence of the aging process. Here, we will highlight the existing understanding of EMT supporting the phenotypical alterations that occur during normal aging or pathogenesis, covering the impact of EMT deregulation in tissue homeostasis and stem cell function.

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Citations

Jul 21, 2020·Journal of Internal Medicine·J L Kirkland, T Tchkonia
Sep 20, 2020·International Journal of Cancer. Journal International Du Cancer·Shadi AzamPer Hall
Nov 24, 2020·BMC Genomics·Flaria El-KhouryJean-René Martin
Feb 10, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Seok Jae LeeJeong Hun Kim
Jan 5, 2021·Precision Clinical Medicine·Tiantian LiuCharles Wang
Feb 9, 2021·Frontiers in Physiology·Francisco SantosBruno Bernardes de Jesus
Dec 4, 2020·Cancers·Bruno Bernardes de JesusSandrina Nóbrega-Pereira
Apr 2, 2021·Investigative Ophthalmology & Visual Science·Srinivasa R SripathiDonald J Zack
Apr 4, 2021·International Journal of Molecular Sciences·Paul E SquiresClaire E Hills
Jun 16, 2021·British Journal of Cancer·Shadi AzamPer Hall
Jun 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lirong LiuShougang Zhuang
Jul 20, 2021·ACS Biomaterials Science & Engineering·Kristen L HaywardBoyang Zhang

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