New Insights into the Role of Exosomes in the Heart After Myocardial Infarction

Journal of Cardiovascular Translational Research
Na LiNathalie Rosenblatt-Velin

Abstract

Intercellular communications play a pivotal role in several cardiac pathophysiological processes. One subtype of extracellular vesicles, so-called exosomes, became known as important intercellular communication mediators in the heart. Exosomes are lipid bilayer biological nanovesicles loaded with diverse proteins, lipids, and mRNAs/microRNAs. All major cardiac cell types can modulate recipient cellular function via the release of exosomes. After myocardial infarction (MI), exosomes, especially those secreted by different cardiac stem cells, have been shown to confer cardioprotective effects, activate regenerative signals, and participate into cardiac repair. In this review, we rapidly recall the biology of exosomes at the beginning. Then we summarize the exosomes secreted by different myocardial cells and their function in cardiac intercellular communication. At last, we discuss the role of these vesicles in cardiac repair after MI.

References

Aug 3, 2002·Nature Reviews. Immunology·Clotilde ThérySebastian Amigorena
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Feb 20, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sanjiv Gupta, A A Knowlton
Jun 6, 2009·Nature Reviews. Immunology·Clotilde ThéryElodie Segura
Feb 9, 2010·Stem Cell Research·Ruenn Chai LaiSai Kiang Lim
May 15, 2010·Journal of Cellular and Molecular Medicine·K R VrijsenP A F M Doevendans
Jun 7, 2011·Circulation. Cardiovascular Genetics·Yasuhide KuwabaraTakeshi Kimura
Jun 10, 2011·Journal of Translational Medicine·Sascha KellerPeter Altevogt
Sep 8, 2011·Journal of Cellular and Molecular Medicine·C G ManoleL M Popescu
Oct 5, 2011·Circulation·Salvatore De RosaAndreas M Zeiher
Feb 14, 2012·Nature Cell Biology·Eduard HergenreiderStefanie Dimmeler
May 19, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Klitos KonstantinidisRichard N Kitsis
Aug 28, 2012·Journal of Molecular and Cellular Cardiology·Yunhui ChengChunxiang Zhang
Dec 12, 2012·Journal of Biomedicine & Biotechnology·Lucio BarileGiuseppe Vassalli
Jan 16, 2013·Biochemical and Biophysical Research Communications·Lijuan ChenYaoliang Tang
Feb 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Z A MalikA A Knowlton
Apr 27, 2013·The Journal of Clinical Investigation·Julie HalkeinIngrid Struman
Sep 7, 2013·Journal of Extracellular Vesicles·Nina GennebäckStellan Mörner
Dec 18, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Suyan BianHepeng Yu
Jan 18, 2014·Circulation Research·Susmita Sahoo, Douglas W Losordo
Jan 18, 2014·Circulation Research·Xavier LoyerChantal M Boulanger
Feb 4, 2014·Cardiovascular Research·Joost P G SluijterPieter A Doevendans
Feb 18, 2014·PloS One·Chao ChengJiahong Xia
Apr 20, 2014·The Journal of Clinical Investigation·Claudia BangThomas Thum
May 16, 2014·Journal of Molecular and Cellular Cardiology·Xiaohong WangGuo-Chang Fan
Jun 18, 2014·Stem Cell Reports·Ahmed Gamal-Eldin IbrahimEduardo Marbán
Jul 19, 2014·Circulation Research·Mélanie VausortYvan Devaux
Sep 23, 2014·Cell Death and Differentiation·C BraicuG A Calin
Oct 29, 2014·Journal of the American Heart Association·Felix JansenNikos Werner
Feb 17, 2015·Trends in Cell Biology·Emanuele Cocucci, Jacopo Meldolesi
Apr 18, 2015·Journal of the American College of Cardiology·Jose M VicencioSean M Davidson
Aug 6, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jamie N Mayo, Shawn E Bearden

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Citations

Jan 9, 2019·Journal of Cardiovascular Translational Research·Jing WangJunjie Xiao
May 28, 2019·International Journal of Molecular Sciences·Loubna MaziniGabriel Malka
Aug 11, 2020·Current Atherosclerosis Reports·Hongyun WangJunjie Xiao
Oct 17, 2019·International Journal of Molecular Sciences·Andrea CaccioppoMaria Felice Brizzi
Apr 26, 2020·Journal of Cardiovascular Translational Research·Nana HeHonghua Ye
Dec 10, 2020·International Journal of Molecular Sciences·Luc RochetteCatherine Vergely
Mar 7, 2021·Cancers·Luc RochetteCatherine Vergely
Aug 28, 2021·International Journal of Molecular Sciences·Luc RochetteCatherine Vergely
Oct 7, 2021·Journal of Cardiovascular Translational Research·Hui MengMingjing Zhao
Nov 9, 2021·Frontiers in Cardiovascular Medicine·Amankeldi A SalybekovTakayuki Asahara

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