New insights into the role of the superficial tangential zone in influencing the microstructural response of articular cartilage to compression

Osteoarthritis and Cartilage
S L BevillN D Broom

Abstract

The purpose of this study was to characterize the microstructural response of healthy cartilage in a perturbed physical environment to compressive loading with a novel channel indentation device. Manipulation of the cartilage physical environment was achieved through (1) removal of the superficial tangential zone (STZ) and (2) varying the saline bathing solution concentration. Cartilage-on-bone blocks were subjected to creep loading under a nominal stress of 4.5 MPa via an indenter consisting of two rectangular platens separated by a narrow channel relief space to create a specific region where cartilage would not be directly loaded. Each sample was fixed in its near-equilibrium deformed state, after which the cartilage microstructure was examined using differential interference contrast (DIC) optical microscopy and scanning electron microscopy (SEM). The cartilage bulge in the channel relief space was studied in detail. STZ removal altered the indentation response at the macro- and microstructural levels. Specifically, the strain in the directly compressed regions was reduced (P=0.012) and the bulge height in the channel relief space was greater (P<0.0001) in the STZ-removed compared with the surface-intact samples. The bulge ...Continue Reading

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Citations

Nov 16, 2013·Journal of Biomechanical Engineering·Mark R BuckleyItai Cohen
May 18, 2013·Tissue Engineering. Part C, Methods·Mehdi KhoshgoftarCorrinus C van Donkelaar
Oct 28, 2011·Cell and Tissue Research·Linda KockKeita Ito
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Nov 20, 2012·Biomechanics and Modeling in Mechanobiology·Mehdi KhoshgoftarCorrinus C van Donkelaar
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Jul 13, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Ashvin ThambyahNeil D Broom
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Jan 1, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Abhinava ChatterjeeSujeet K Sinha

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