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New insights into the role of TREM2 in Alzheimer's disease

Molecular Neurodegeneration

Dec 24, 2018

Maud GratuzeDavid M Holtzman

Abstract

Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and neurofibrillary tangles of aggregated, abnormally hyperphosphorylated tau protein. The majority of AD cases are late-onset, ...read more

Mentioned in this Paper

Biological Markers
Study
Familial Alzheimer Disease (FAD)
Pathogenesis
Neurofibrillary Degeneration (Morphologic Abnormality)
Molecular_function
Myeloid Cells
Alzheimer's Disease
TREM2
Receptor Expression
20
1
1
147
Paper Details
References

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New insights into the role of TREM2 in Alzheimer's disease

Molecular Neurodegeneration

Dec 24, 2018

Maud GratuzeDavid M Holtzman

PMID: 30572908

DOI: 10.1186/s13024-018-0298-9

Abstract

Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and neurofibrillary tangles of aggregated, abnormally hyperphosphorylated tau protein. The majority of AD cases are late-onset, ...read more

Mentioned in this Paper

Biological Markers
Study
Familial Alzheimer Disease (FAD)
Pathogenesis
Neurofibrillary Degeneration (Morphologic Abnormality)
Molecular_function
Myeloid Cells
Alzheimer's Disease
TREM2
Receptor Expression
20
1
1
147

Similar Papers Found In These Feeds

/papers/new-insights-into-the-role-of-trem2-in-alzheimers/30572908