New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation.

Seminars in Cell & Developmental Biology
Lai WeiJohn J O'Shea

Abstract

T cell development and differentiation is carefully orchestrated by a series of cytokines. The importance of STAT family proteins in mediating signals by these cytokines is well-known, but new information on the role of STATs in novel aspects of T cell function and T cell subsets continues to accumulate. Recent studies have placed Stat5a/b and Stat3 center stage in T cell development and differentiation. Stat5a/b are indispensable in T regulatory (Treg) cell development and maintenance, and negatively regulate T helper 17 (Th17) cell differentiation. Conversely, Stat3 is essential for Th17 differentiation and inhibits Treg cells. The balance of Treg and Th17 cells is thought to be critical in maintaining immune tolerance, while preserving effective host defense. Therefore, Stat5a/b and Stat3 are emerging to be key players in T cell differentiation and homeostasis.

References

Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
Jul 7, 1995·The Journal of Biological Chemistry·C PallardI Dusanter-Fourt
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·J P DiSantoK Rajewsky
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·B Happ, B Groner
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·M MinamiS Akira
Sep 1, 1995·Research in Immunology·N G JacobsonK M Murphy
Jan 15, 1997·Genes & Development·X LiuL Hennighausen
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·K TakedaS Akira
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·G B UdyH W Davey
Dec 8, 1998·The Journal of Experimental Medicine·K ImadaW J Leonard
Jun 22, 1999·Cellular Signalling·R JasterJ Brock
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·A A LighvaniJ J O'Shea
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·David E Levy, J E Darnell
Feb 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thomas WelteXin-Yuan Fu
Mar 4, 2003·Nature Immunology·Roli KhattriFred Ramsdell
Mar 19, 2003·The Journal of Experimental Medicine·Lynda BennettVirginia Pascual

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Citations

Oct 5, 2010·Clinical & Developmental Immunology·Mingli XuTakayuki Yoshimoto
Aug 12, 2014·Journal of Physiology and Biochemistry·Xuehua TangTingting Wang
Jul 18, 2009·Journal of the American Society of Nephrology : JASN·Xiaobei FengJohn C He
Sep 26, 2009·Blood·Akiko KimuraLothar Hennighausen
Oct 8, 2009·Nature Reviews. Immunology·Jeffrey A BluestoneBrigitta Stockinger
Sep 22, 2010·PLoS Biology·Emily CorseJames P Allison
Feb 6, 2013·Infection and Immunity·Ranjani PrabhakaraTod J Merkel
Jan 25, 2012·The Journal of Experimental Medicine·Robert J JohnstonShane Crotty
Jun 27, 2012·Cancer Immunology, Immunotherapy : CII·Katarina LuptakovaDavid Avigan
Sep 11, 2012·American Journal of Otolaryngology·Xiao-Qiang WangSu-Ling Hong
Dec 27, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A M ManzardoM G Butler
Jan 24, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Tan LiShu-Fang Bai
Nov 30, 2011·International Immunopharmacology·Tan LiYa-xun Zhou
Aug 20, 2011·Current Opinion in Immunology·Greg M DelgoffeDario A A Vignali
Dec 1, 2010·International Immunopharmacology·Marc Beyer, Joachim L Schultze
Mar 3, 2010·Biochimica Et Biophysica Acta·Patrick M Brauer, Angela L Tyner
Oct 18, 2015·Rheumatic Diseases Clinics of North America·Darren D O'Rielly, Proton Rahman
Mar 7, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·O BoenischN Najafian
Aug 16, 2014·Immunological Reviews·Han-Yu ShihJohn J O'Shea
Sep 7, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Jahaira Lopez-PastranaXiao-Feng Yang
Aug 16, 2011·Transplantation Proceedings·S J ParkY H Kim
Aug 3, 2012·Cytokine·Aurélie Jeanne TormoJean-François Gauchat
Mar 17, 2015·Nature Communications·Federico MeleSilvia Monticelli
May 31, 2017·European Journal of Immunology·Katharina WelschKamran Ghoreschi
Jun 28, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jian YeGuangyong Peng
May 10, 2018·Molecular Ecology·Sergio F Nigenda-MoralesRobert K Wayne
Sep 20, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yu LongQun Du
Jul 27, 2018·Annals of the Rheumatic Diseases·Shengwei JinJianguang Wang

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