New insights into the upward vestibulo-oculomotor pathways in the human brainstem

Progress in Brain Research
Charles Pierrot-Deseilligny, Caroline Tilikete

Abstract

The brainstem vestibulo-oculomotor pathways are not yet fully known. Three different excitatory tracts could be involved in the transmission of upward vestibular eye movement (VEM) signals and upward eye position (EP) signals to the oculomotor nucleus (III): the medial longitudinal fasciculus (MLF), the brachium conjunctivum (BC), and the crossing ventral tegmental tract (CVTT). The involvement of the MLF pathway originating in the medial vestibular nucleus (MVN) in this transmission is experimentally and clinically well established whereas a role of the BC appears to be questionable. Furthermore, there is now accumulating evidence that the CVTT pathway emerging from the superior vestibular nucleus (SVN) also plays an important role in the mediation of excitatory upward EP and VEM signals to the III. This duplication of pathways (MVN-MLF and SVN-CVTT) could be explained by a supplementary and relatively specific function performed by the SVN-CVTT pathway to counteract the gravity pull in the upward eye movement system. Various arguments in support of this hypothesis are reviewed.

Citations

Nov 26, 2010·Current Opinion in Neurology·Caroline Tilikete, Alain Vighetto
Feb 19, 2009·Journal of Neurology·Patrick Yu-Wai-ManPatrick F Chinnery
Jul 20, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ettore SalsanoDavid S Zee
May 23, 2013·The Journal of Comparative Neurology·Christina ZeehAnja K E Horn
Sep 29, 2011·Annals of the New York Academy of Sciences·Julia AhlfeldAnja K E Horn
Aug 4, 2009·Annals of the New York Academy of Sciences·C Pierrot-Deseilligny
Oct 2, 2021·Frontiers in Integrative Neuroscience·Max GattieKarolina Kluk

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