New insights into the vascular mechanisms underlying the beneficial effect of swimming training on the endothelial vasodilator function in apolipoprotein E-deficient mice

Atherosclerosis
Maxime PellegrinPascal Laurant

Abstract

The antiatherogenic role of exercise is poorly understood. We examined the swimming exercise-induced vascular mechanisms which enhance the endothelial vasodilator function in apoE(-/-) mice. Male apoE(-/-) mice treated for 9 weeks with a lipid-rich diet were divided into two groups: the exercise group (apoE(-/-) X), which underwent a 9-week swimming protocol (50 min/day; 5days/week) and the sedentary group (apoE(-/-) S). C57BL/6 mice were used as the control group. Atherosclerotic lesions in the aortic roots were significantly reduced in apoE(-/-) X compared to apoE(-/-) S. Relaxation to acetylcholine was improved in apoE(-/-) X as compared to apoE(-/-) S and control mice with E(max) and pD(2) values significantly higher. pD(2) values in response to papaverine were higher in apoE(-/-) X than in the other groups. Relaxation in response to A23187 and DEA-NONOate were similar. These findings suggest that swimming training may increase the sensitivity of relaxation to acetylcholine, which in turn activates acetylcholine-mediated signaling pathways leading to increased NO bioactivity. Swimming may also prolong the signaling actions of NO by stimulating the sensitivity of vascular smooth muscle cells to cyclic nucleotides. These appe...Continue Reading

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Citations

Sep 27, 2012·Journal of Physiology and Biochemistry·François GuerreroJacques Mansourati
Nov 16, 2011·Lipids in Health and Disease·Silvana S MeyrellesElisardo C Vasquez
Nov 17, 2009·Medicine and Science in Sports and Exercise·Maxime PellegrinPascal Laurant
Dec 28, 2010·Canadian Journal of Physiology and Pharmacology·Maxime PellegrinPascal Laurant
Jul 7, 2011·Clinical Science·Justyna Szostak, Pascal Laurant
Jan 23, 2015·Frontiers in Cell and Developmental Biology·Alexei V NosarevLeonid V Kapilevich
May 14, 2008·Current Hypertension Reports·Hong LuAlan Daugherty
Jan 2, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Gurneet S SanghaAlisa M Clyne
Jun 5, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mitsuharu OkutsuKei Nagashima
Jan 22, 2021·The Journal of Sports Medicine and Physical Fitness·Onur Oral

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