New Insights Into Tissue Macrophages: From Their Origin to the Development of Memory

Immune Network
Paola Italiani, Diana Boraschi

Abstract

Macrophages are the main effector cells of innate immunity and are involved in inflammatory and anti-infective processes. They also have an essential role in maintaining tissue homeostasis, supporting tissue development, and repairing tissue damage. Until few years ago, it was believed that tissue macrophages derived from circulating blood monocytes, which terminally differentiated in the tissue and unable to proliferate. Recent evidence in the biology of tissue macrophages has uncovered a series of immune and ontogenic features that had been neglected for long, despite old observations. These include origin, heterogeneity, proliferative potential (or self-renewal), polarization, and memory. In recent years, the number of publications on tissue resident macrophages has grown rapidly, highlighting the renewed interest of the immunologists for these key players of innate immunity. This mini-review aims to summarizing the new current knowledge in macrophage immunobiology, in order to offer a clear and immediate overview of the field.

References

Nov 1, 1988·Journal of Leukocyte Biology·M J MelnicoffP S Morahan
Jan 1, 1987·The Journal of Investigative Dermatology·J M Czernielewski, M Demarchez
Sep 1, 1968·The Journal of Experimental Medicine·R van Furth, Z A Cohn
Nov 1, 1984·The Journal of Experimental Medicine·R van Furth, M M Diesselhoff-den Dulk
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
May 16, 2003·Nature·William J BoyleDavid L Lacey
Jul 31, 2004·Annual Review of Phytopathology·W E Durrant, X Dong
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
Dec 3, 2005·Nature Reviews. Immunology·Siamon Gordon, Philip R Taylor
Aug 26, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anna Simon, Jos W M van der Meer
Jan 5, 2007·Annual Review of Immunology·Ana Cumano, Isabelle Godin
Jun 1, 2007·Nature·Simmie L FosterRuslan Medzhitov
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Fernando Oneissi MartinezMassimo Locati
Nov 21, 2007·Microbes and Infection·D M E BowdishS Gordon
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Mar 24, 2009·Annual Review of Immunology·Seth L MastersDaniel L Kastner
Sep 22, 2010·Nature Immunology·Subhra K Biswas, Alberto Mantovani
May 18, 2011·Cell Host & Microbe·Mihai G NeteaJos W M van der Meer
Jun 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Klaus LeyCatherine C Hedrick
Oct 15, 2011·Nature Reviews. Immunology·Peter J Murray, Thomas A Wynn
Oct 26, 2011·Nature Reviews. Immunology·Toby Lawrence, Gioacchino Natoli
Mar 2, 2012·The Journal of Clinical Investigation·Antonio Sica, Alberto Mantovani
Mar 24, 2012·Science·Christian SchulzFrederic Geissmann
Apr 10, 2012·Cell Metabolism·Subhra K Biswas, Alberto Mantovani
Sep 19, 2012·The Canadian Journal of Cardiology·Brian W WongBruce M McManus
Feb 6, 2013·Frontiers in Immunology·Loems Ziegler-Heitbrock, Thomas P J Hofer
Feb 23, 2013·Critical Reviews in Immunology·Charles D Mills
Mar 13, 2013·Trends in Immunology·Ehud Zigmond, Steffen Jung
Mar 20, 2013·Frontiers in Cellular Neuroscience·Yochai WolfSteffen Jung
Jun 19, 2013·Nature Immunology·Noelia A-GonzalezAntonio Castrillo
Sep 28, 2013·Advances in Immunology·Kaaweh Molawi, Michael H Sieweke
Oct 15, 2013·Cold Spring Harbor Symposia on Quantitative Biology·Elisa Gomez Perdiguero, Frederic Geissmann
Nov 28, 2013·Seminars in Immunology·Charles A Dinarello, Jos W M van der Meer
Dec 10, 2013·Nature Neuroscience·Oleg ButovskyHoward L Weiner
Mar 29, 2014·F1000prime Reports·Fernando O Martinez, Siamon Gordon
Jul 19, 2014·Nature Reviews. Immunology·Martin GuilliamsSimon Yona

❮ Previous
Next ❯

Citations

Mar 5, 2016·Scientific Reports·Mehboob AliLynette K Rogers
Apr 2, 2016·Mediators of Inflammation·Xueli FanTao Jin
May 14, 2016·International Immunopharmacology·Rajapaksha Gedara Prasad Tharanga JayasooriyaGi-Young Kim
Aug 25, 2016·Drug Discovery Today·Urmi PatelJohnson Rajasingh
Mar 13, 2012·Medical Hypotheses·María-Angeles AllerJaime Arias
Aug 5, 2017·Innate Immunity·Serge DionneErnest G Seidman
Feb 1, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hwa I HanNeil A Hukriede
Jan 31, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Layla NabaiAziz Ghahary
Sep 20, 2020·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Nagoud SchukfehGertrud Vieten
Sep 10, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Mi-Yeon Kim, Jae Youl Cho
Nov 29, 2016·Frontiers in Immunology·Mieke MetzemaekersPaul Proost
Jul 7, 2017·Mediators of Inflammation·Jae Gwang ParkJae Youl Cho
Nov 4, 2020·International Journal of Molecular Sciences·Roya RasaeiSeok-Ho Hong
Jun 3, 2021·International Journal of Molecular Sciences·Sarah Cunningham, Holger Hackstein
Jul 17, 2021·Frontiers in Immunology·Qi ZhangTingbo Liang

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-seq

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Expert Review of Clinical Immunology
Javier CondeOreste Gualillo
Transplantation
Ajda Tahereh Rowshani, Elly Johanna Francisca Vereyken
Frontiers in Physiology
Jonathan JantschJens Titze
Nihon rinsho. Japanese journal of clinical medicine
Tetsuro Okabe
© 2021 Meta ULC. All rights reserved