New insights into type I interferon and the immunopathogenesis of persistent viral infections

Current Opinion in Immunology
Laura M Snell, David G Brooks

Abstract

Most viruses generate potent T cell responses that rapidly control infection. However, certain viruses can subvert the immune response to establish persistent infections. The inability to clear virus induces an immunosuppressive program leading to the sustained expression of many immunoregulatory molecules that down-regulate T cell responses. Further, viral persistence is associated with multiple immune dysfunctions including lymphoid disorganization, defective antigen presentation, aberrant B cell responses and hypergammaglobulinemia. Although best known for its antiviral activity, recent data has highlighted the role of type I IFN (IFN-I) signaling as a central mediator of immunosuppression during viral persistence. It is also becoming increasingly apparent that many of the immune dysfunctions during persistent virus infection can be attributed directly or indirectly to the effects of chronic IFN-I signaling. This review explores the increasingly complex role of IFN-I in the regulation of immunity against persistently replicating virus infections and examines current and potential uses of IFN-I and blockade of IFN-I signaling to dampen chronic inflammation and activation in the clinic.

References

May 3, 2005·Nature Reviews. Immunology·Leonidas C Platanias
Sep 1, 2005·The Journal of Experimental Medicine·Ganesh A KolumamKaja Murali-Krishna
Dec 29, 2007·The Journal of Pathology·V Appay, D Sauce
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
May 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Magdalena Sarasin-FilipowiczMarkus H Heim
Jul 25, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Adriano BoassoGene M Shearer
Sep 15, 2010·The Journal of Experimental Medicine·Giorgio Trinchieri
Sep 25, 2010·The Journal of Infectious Diseases·J Judy Chang, Marcus Altfeld
May 4, 2011·The Journal of Experimental Medicine·Laura M FaheyDavid G Brooks
Aug 28, 2012·The Journal of Clinical Investigation·Constantinos PetrovasRichard A Koup
Aug 28, 2012·The Journal of Clinical Investigation·Madelene LindqvistHendrik Streeck
Apr 13, 2013·Science·John R TeijaroMichael B A Oldstone
Jun 19, 2013·Immunological Reviews·Nichole R KlattSteven G Deeks
Aug 27, 2013·Cell Cycle·Elizabeth B Wilson, David G Brooks
Feb 22, 2014·Annual Review of Immunology·William M SchneiderCharles M Rice
May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ivan OsokineDavid Brooks
May 29, 2014·Science Signaling·Doron LevinGideon Schreiber
Dec 17, 2014·Clinical & Translational Immunology·Lilian ChaMartyn A French

❮ Previous
Next ❯

Citations

Jul 6, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Giulia MarsiliAngela Battistini
Apr 11, 2018·Clinical & Translational Immunology·Ran WangSumaira Z Hasnain
Nov 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Paula ArayaJoaquín M Espinosa
Dec 10, 2019·The Journal of Experimental Medicine·Hector Huerga EncaboCristina López-Rodríguez
Jul 16, 2020·PloS One·Vibha TanejaHanumanthappa Krishna Prasad
Dec 14, 2018·Virologica Sinica·Dengyuan ZhouJing Ye
Feb 23, 2019·Viruses·Tamara Suprunenko, Markus J Hofer
May 15, 2018·Frontiers in Immunology·Mayra A CarrilloScott G Kitchen
Sep 4, 2020·The Journal of Experimental Medicine·Bethany L MacleodDavid G Brooks
Mar 16, 2017·Frontiers in Immunology·Mohammedyaseen Syedbasha, Adrian Egli
Feb 26, 2020·Proceedings of the National Academy of Sciences of the United States of America·Heidi J ElsaesserDavid G Brooks
Mar 28, 2017·Veterinary Microbiology·Hanzhong Ke, Dongwan Yoo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis