New insights of Helicobacter pylori host-pathogen interactions: The triangle of virulence factors, epigenetic modifications and non-coding RNAs

World Journal of Clinical Cases
Farzam VaziriSeyed Davar Siadat

Abstract

Helicobacter pylori (H. pylori) is a model organism for understanding host-pathogen interactions and infection-mediated carcinogenesis. Gastric cancer and H. pylori colonization indicates the strong correlation. The progression and exacerbation of H. pylori infection are influenced by some factors of pathogen and host. Several virulence factors involved in the proper adherence and attenuation of immune defense to contribute the risk of emerging gastric cancer, therefore analysis of them is very important. H. pylori also modulates inflammatory and autophagy process to intensify its pathogenicity. From the host regard, different genetic factors particularly affect the development of gastric cancer. Indeed, epigenetic modifications, MicroRNA and long non-coding RNA received more attention. Generally, various factors related to pathogen and host that modulate gastric cancer development in response to H. pylori need more attention due to develop an efficacious therapeutic intervention. Therefore, this paper will present a brief overview of host-pathogen interaction especially emphases on bacterial virulence factors, interruption of host cellular signaling, the role of epigenetic modifications and non-coding RNAs.

References

Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A CovacciN Figura
Oct 18, 2000·Regulatory Peptides·T J Koh, D Chen
Jan 13, 2006·International Journal of Cancer. Journal International Du Cancer·Donald Maxwell Parkin
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takao MaekitaToshikazu Ushijima
Aug 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konstantin D TaganovDavid Baltimore
Sep 11, 2007·Digestive Diseases·Gerardo NardoneAlba Rocco
Nov 17, 2007·Genes & Development·Noboru Mizushima
Feb 19, 2008·Trends in Microbiology·Xaver SewaldRainer Haas
Sep 17, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Zhiyu ZhangHong Lu
Oct 29, 2008·Genome Research·Robin C FriedmanDavid P Bartel
Jan 5, 2010·The Tohoku Journal of Experimental Medicine·Hajime IsomotoToshiya Hirayama
Jan 19, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Lina Fassi FehriThomas F Meyer
Mar 25, 2010·International Journal of Cancer. Journal International Du Cancer·Kayoko MatsushimaShigeru Kohno
Jul 29, 2010·Physiological Reviews·Richard M PeekKeith T Wilson
Oct 13, 2010·Nature Reviews. Gastroenterology & Hepatology·Yoshio Yamaoka
Jan 1, 2010·Frontiers in Microbiology·Kathleen R JonesD Scott Merrell
Oct 8, 2011·Communicative & Integrative Biology·Marjan M TajrishiNarendra Tuteja
Apr 24, 2012·Molecular Microbiology·Sarah TalaricoNina R Salama
Oct 13, 2012·Gastroenterology·Alfred S L ChengFrancis K L Chan
Nov 13, 2012·Journal of Cancer Research and Clinical Oncology·Feng YangGuoen Fang
Apr 10, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Farzam VaziriMohammad Reza Zali
Jul 13, 2013·Experimental & Molecular Medicine·Seong-Min ParkSeon-Young Kim
Sep 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ming SunXianghua Liu
Sep 18, 2013·Helicobacter·Trinidad Parra CidNicola L Jones
Sep 17, 2013·World Journal of Gastroenterology : WJG·Farzam VaziriMohammad Reza Zali

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Citations

May 30, 2020·International Journal of Molecular Sciences·Lea DenzerChristian Schwerk
Jan 4, 2020·Experimental and Molecular Pathology·Soudeh Ghafouri-Fard, Mohammad Taheri

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Methods Mentioned

BETA
acetylation
histone acetylation

Software Mentioned

GAPLINC

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