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New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation

Biochemical Pharmacology

Apr 30, 2019

Cong Liu, Yanshan Fang

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PubMed

Abstract

Abnormal protein aggregation is a common pathological feature of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). Protein posttranslational modifications (PTMs) play a crucial regula...read more

Mentioned in this Paper

Hemodialysis
Post-Translational Protein Processing
Nerve Degeneration
PARP1 protein, human
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
NEDD8-Activating Enzyme E1 Regulatory Subunit
Protein Aggregation, Pathological
Poly(ADP)-ribosylated proteins
Parkinson Disease
2
1
17
Paper Details
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New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation

Biochemical Pharmacology

Apr 30, 2019

Cong Liu, Yanshan Fang

PMID: 31034795

DOI: 10.1016/j.bcp.2019.04.028

Abstract

Abnormal protein aggregation is a common pathological feature of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). Protein posttranslational modifications (PTMs) play a crucial regula...read more

Mentioned in this Paper

Hemodialysis
Post-Translational Protein Processing
Nerve Degeneration
PARP1 protein, human
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
NEDD8-Activating Enzyme E1 Regulatory Subunit
Protein Aggregation, Pathological
Poly(ADP)-ribosylated proteins
Parkinson Disease
2
1
17

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